Heart Rate Variability and Electroencephalography Analysis in Laparoscopic Surgery With or Without Transversus Abdominis Plane Block

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04539080

Enrollment

Registered

2020-09-04

Start date

2020-08-30

Completion date

2023-08-30

Last updated

2023-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia and Analgesia, Autonomic Nervous System, EEG, Laparoscopy, Nerve Block

Brief summary

Heart rate variability(HRV) and electroencephalography(EEG) has been used widely in anesthetic practice nowadays. One of the most dominant applications is the nociception-analgesia balance. Some evidence support that heart rate variability correlates with perioperative stimulation and postoperative pain score. There are some new evidence support EEG correlated with anesthesia depth and analgesic balance. However, the heterogeneity between the studies and interference factors has limited their usage in clinical practice. On the other hand, peripheral nerve block is broadly used as a routine technique with general anesthesia, but few studies discuss the effect on heart rate variability. Our study focuses on the different HRV and EEG patterns of incision and insufflation during laparoscopic surgery with general anesthesia. Furthermore, we measure the effect of transversus abdominis plane nerve block to heart rate variability during surgery. By this comparison, we can discuss the influences of somatic stimulation, visceral stimulation, and pneumoperitoneum to heart rate variability, and then improve the accuracy of HRV-based nociception-analgesia monitors.

Interventions

PROCEDUREtransversus abdominis plane block

transversus abdominis plane block group

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* ≥20 years of age male or female * American Society of Anesthesiologists (ASA) physical status classification I or II * capacity to give informed consent

Exclusion criteria

* major cardiovascular and cerebral vascular disease, arrhythmia, respiratory disease, diabetes mellitus with evidence of neuropathy; ASA physical status classification III or greater; a documented or self-reported history of chronic pain; acute or chronic opioid analgesic use; dysautonomia; and intraoperative muscarinic anticholinergic administration during the time of monitoring.

Design outcomes

Primary

Measure	Time frame	Description
Different heart rate variability pattern during laparoscopy	6 months	Different heart rate variability pattern in incision and inflation with or without TAP block

Countries

Taiwan

Contacts

Primary ContactTzu-Chun Wang, MD

ff_west@hotmail.com+886-02-2543-3535

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026