Bronchiectasis Adult
Conditions
Brief summary
Bronchiectasis is associated with repeated exacerbations which occurs at rates of 1.5-6.5 per patients per year, and are associated with an increased risk of admission and readmission to hospital, and high health care costs. In a local study carried out more than 10 years ago, idiopathic disease dominates and patients with bronchiectasis are mainly female with high hospitalization and mortality rates; 21.9 cases per 100,000 and 2.7 cases per 100,000 respectively. Moreover, exacerbation characterized by increases in symptoms requiring antibiotic treatment is associated with disease progression and significant mortality. Updated prevalence of this disease with the characteristics of etiology, clinical presentation and outcomes are needed to guide further management plan.
Interventions
None listed
Sponsors
Chinese University of Hong Kong
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients aged 18 years or older 2. Clinically stable for at least 4 weeks prior to enrollment (defined as no symptoms of exacerbation, no requirement for supplemental antibiotic therapy) 3. Diagnosis of bronchiectasis defined by high-resolution computed tomography scan
Exclusion criteria
1. History of cystic fibrosis; hypogammaglobulinemia; allergic bronchopulmonary aspergilosis 2. Those who are unable to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of bronchiectasis exacerbation | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| Mortality rate | 5 years |
Countries
Hong Kong
Outcome results
None listed