Pre-surgical Antisepsis of Hands After Washing With Triclosan 0.5% Compared to Propan-1-ol 60%

Effect on the Reduction of Bacterial Load in Surgical Antisepsis of Hands After Washing With Triclosan 0.5% Compared to Propan-1-ol 60% Used as Reference Disinfectant

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04538365

Enrollment

Registered

2020-09-04

Start date

2020-10-01

Completion date

2020-10-30

Last updated

2020-11-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antisepsis

Keywords

hand washing, presurgical antisepsis

Brief summary

The present study evaluates the effects of bactericidal load reduction after surgical hand scrub antisepsis using the reference antiseptic product propanol- 1 60% as control versus a surgical hand scrub antisepsis with triclosan 0.5% in order to test if pass the standard european norm 12791.

Detailed description

The investigators conducted a crossover clinical trial to evaluate the antiseptic effectiveness of preoperative surgical scrubbing using propan-ol-1 60% by scrub using the reference antiseptic product propan-ol-1 60% as control versus a surgical hand scrub antisepsis with trocilosan 0.5% in order to test if pass the standard european norm 12791. Samples will be taken from the hands of each volunteer after a surgical hands antiseptic.

Interventions

DRUGTriclosan 0.5 % Topical Solution

Hand antisepsis by scrub Surgical Hand scrubbing using triclosan 0.5% solution both hands using a sterile disposable surgical scrub brush with plastic bristles on one side and a foam sponge on the other side

DRUGpropanolol

Hand antisepsis by scrub Surgical Hand scrubbing using Propanolol 60% solution both hands using a sterile disposable surgical scrub brush with plastic bristles on one side and a foam sponge on the other side

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Masking description

The samples will be sent to the laboratory with numbers

Intervention model description

Crossover design is used

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* Participants without systemic pathologies, with healthy skin of the hands and short fingernails. * They do not use substances with antibacterial action.

Exclusion criteria

* Taken antibiotics before 10 days of the intervention. * Wear any jewellery on the hands

Design outcomes

Primary

Measure	Time frame	Description
Reduction of bacterial load immediately after hand scrub	Change from bacterial load at 5 minutes	Participants will scrub with the antiseptic solution vigorously from hand to the wrists according with the standard handscrub procedure

Secondary

Measure	Time frame	Description
Reduction of bacterial load after 3 hours of hand scrub	Change from bacterial load after 3 hours	Participants will scrub with the antiseptic solution vigorously from hand to the wrists according with the standard handscrub after 3 hours

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 13, 2026