Breast Cancer, Radiotherapy Side Effect
Conditions
Brief summary
Adjuvant radiotherapy after breast conserving surgery has been shown to improve both local control and overall survival. Dose escalation of the tumor bed by addition of a boost after whole breast radiotherapy reduces the risk of local recurrence in invasive breast cancer. Simultaneous integrated boost (SIB) techniques have been shown to provide more conformal treatment plans than conventional sequential boost, in addition, SIB enables a reduction in the overall treatment time by 1 week compared to conventional boost techniques. The proposed study is aimed at evaluating radiation-induced toxicity in patients treated with breast-conserving surgery in combination with radiotherapy using SIB technique.
Interventions
RADIATIONSimultaneous integrated boost
Adjuvant breast cancer irradiation including simultaneous integrated boost
Sponsors
Medical University of Graz
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Invasive breast cancer or ductal carcinoma in situ * Breast conserving surgery * Complete tumor resection * Treatment with adjuvant radiotherapy of the breast * Indication for boost Irradiation * Given informed consent
Exclusion criteria
* Incomplete tumor resection * Mastectomy * Distant metastases at diagnosis * Unable to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute Radiation induced toxicity (grade 2 or higher) | Measurement at the last 1 day of radiotherapy | Toxicity score using Common Terminology for Adverse Events (CTCAE) |
Countries
Austria
Outcome results
None listed