Acne, Acne Vulgaris
Conditions
Keywords
antioxidants, acne
Brief summary
Antioxidants have been studied for their abilities to combat reactive oxygen species in a multitude of conditions. This study aims to assess whether the botanical dietary supplement 'Halo Beauty Kiwi Booster' (HBKB), taken orally daily for 8 weeks, can assist with Acne vulgaris as well as skin hydration and quality of life for those with acne.
Detailed description
The study will be a 2-armed investigational trial with one group receiving botanical dietary supplement and one placebo group provided with the similar supplement vehicle. The trial will be double-blind, randomized, parallel-group study. The investigational group will receive the botanical dietary supplement 'Halo Beauty Kiwi Booster' (HBKB), to be taken orally daily for 8 weeks. Control group participants will receive the HBKB botanical dietary supplement vehicle as a placebo to be taken orally daily for 8 weeks.Participants will have their skin assessed
Interventions
DIETARY_SUPPLEMENTHBKB Capsule
The botanical dietary supplement 'Halo Beauty Kiwi Booster' (HBKB) taken daily orally.
OTHERHBKB Supplement Vehicle
Control group participants will take one capsule of the HBKB botanical dietary supplement vehicle orally, once daily
Sponsors
University of California, Los Angeles
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
This will be a 2-armed investigational group (botanical dietary supplement) and placebo group (supplement vehicle), double-blind, randomized, parallel-group study.
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults 18-35 years of age able to provide consent to participate * IGA of mild to moderately severe facial Acne Vulgaris (AV) at screening * Potential participants with mild to moderately severe facial AV and with AV on their neck, shoulders, chest and/or back body surface areas may be included.
Exclusion criteria
* An Investigator Global Assessment IGA of severe facial, neck, back or truncal AV * Diagnosis of a chronic inflammatory disease such as lupus, multiple sclerosis, cancer, Chron's disease or cancer * Allergies to Astaxanthin (microalgae), Grape Seed Extract, Kiwi fruit or Kiwi extract, Pineapple fruit or extract (bromelain), Rosehip or Rosehip extract, Gooseberry, Rosehip, Grapes * Secondary AV, such as occupational AV, steroid induced AV, or AV associated with endocrine disorders * Having facial dermatosis that may interfere evaluations by IGA such as sunburn, eczema, psoriasis, erythematotelangectatic rosacea or seborrheic dermatitis * Use of isotretinoin within 2 months * Use of adapalene or tretinoin within 2 weeks * Use of anti-biotics within 2 weeks * Use of oral corticosteroids or androgens within 2 weeks * Use of anticonvulsants * Any subject who the PI deems unsuitable for any reason
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Botanical Impact on hydration in those with Acne Vulgaris | 8 weeks | To prospectively appraise changes in stratum corneum hydration levels in persons with Acne Vulgaris (AV) after dietary supplementation with a compilation of botanical antioxidants. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Botanical Impact on Acne Vulgaris | 8 weeks | To prospectively appraise changes in Investigator Global Assessment (IGA) of Facial AV after dietary supplementation with a compilation of botanical antioxidants.Scale is 0-4 (0 - clear and 4 - severe) |
| Botanical Impact on Quality of Life in those with Acne | 8 weeks | To prospectively appraise changes in AV related quality-of-life (AVQoL) after dietary supplementation with a compilation of botanical antioxidants. |
Countries
United States
Outcome results
None listed