Healthy Aged Volunteers
Conditions
Keywords
Aged people, Exercises, Resistance exercise, Flexibility training, Inflammation
Brief summary
This study aims to identify the mechanisms by which physical exercise can counter inflammation and improve immune function in older persons. These mechanisms will be investigated to develop exercise-based/derived strategies to improve recovery of older patients suffering from immunosenescence and/or immune suppression. In this randomized controlled trial, the effects of resistance exercise (RE) on inflammation and chronic low-grade inflammation (CLIP) will be investigated. The investigators expect that exercise-induced changes in immunosenescence will be reflected by changes in the various domains of interest: 1) the expression of immunosenescence-related genes in PMBC, in circulating markers of inflammation and in PMBC behaviour following LPS stimulation, 2) the proportion of circulating PMBC showing surface and/or intracellular markers for cell senescence, and 3) markers reflecting alterations at the level of the extracellular matrix. Additionally, the investigators want to verify whether 1) resistance exercise improves inflammation and immunosenescence in skin tissue, and 2) resistance exercise improves the stress response in skin tissue after an in-vivo inflammatory challenge by saline injection. The results of this project will allow us to provide new insights in the complex interaction between physical exercise and immunosenescence as well as to present evidence-based guidelines for exercise in elderly persons to counter CLIP
Interventions
OTHERIntensive Strength Training (IST)
OTHERStrength Endurance Training (SET)
OTHERFlexibility Training (FT)
Sponsors
Vrije Universiteit Brussel
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Aged people (male or female) living independently in the community; * Aged ≥65yrs.
Exclusion criteria
* Performing currently or within the past six months on a regular basis physical exercise at higher intensities than habitual daily activity (e.g. fitness classes, strengthening exercises, cycling club); * Presenting contra-indications for any of the exercise interventions; * Cognitive impairment (unable to understand or execute the test/exercise instructions due to cognitive impairment (MMSE\<24/30)); * Presenting physical disability; * Using anti-inflammatory and/or immunosuppressive medication * Presenting an acute inflammatory condition (CRP \>10mg/L)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peripheral blood of older adults will be investigated by qPCR to reveal changes in the inflammatory profile | Change from Baseline inflammatory profile at 6 weeks | The primary objective is to investigate the effects of strength training on inflammation- and immunosenescence-related genes in peripheral blood mononuclear cells |
Countries
Belgium
Contacts
Primary ContactIvan Bautmans, PhD
Outcome results
None listed