Propranolol and Misoprostol Versus Misoprostol Alone for Induction of Labor in Primigravidas

Induction of Labor Affected Fetus / Newborn

To compare propranolol and misoprostol versus misoprostol alone for induction of labour in primigravidas

Candidates will be randomized into 2 groups according to a computer generated sequence. Each candidate will be assigned an opaque sealed envelope containing a paper with her group on it. Both the patient and doctor on duty will be blinded to which group the patient was assigned to. \- Study procedure: 1. Written informed consent will be obtained from all participants prior to the study. 2. Full history taking. 3. General examination. Patients will be subjected to the following: * Patients attending labour room for induction of labour will be divided into two groups. * Both groups, women are induced with Tab misoprostol 25μg applied to posterior vaginal fornix under aseptic precaution and every 6 hours for a maximum of 4 doses. * In group 1, after induction is started with misoprostol placement, 30 minutes will pass before administration of oral Propanolol 20mg * In group 2, after induction is started with misoprostol placement, 30 minutes will pass before administration of oral placebo in the form of sugary tablets. * After induction, women will be monitored for fetal and maternal wellbeing and progress of labour.

Egypt