Influenza, Respiratory Tract Infections
Conditions
Keywords
Vaccination, Reminder recall, Patient Portal
Brief summary
This trial is taking place in Los Angeles, CA among patients from primary care practices within the UCLA Health System. The study design is a 2x2x2 factorial design, nested in a parallel 2-arm trial. The parallel arms are control v. reminder letter (reminder messages sent via the patient portal, reminding participants of an overdue influenza vaccine) Nested within the reminder letter arm, we will have 3 additional components: * A direct scheduling link within the reminder letter enabling the patient to schedule an influenza vaccine only visit (direct scheduling link vs. no direct scheduling link). * A pre-commitment prompt (pre-commitment prompt vs. no prompt) asking about a patient's intention to get the influenza vaccination * A pre-appointment reminder, encouraging patients to ask for their influenza vaccine at their upcoming appointment (pre-appointment reminder encouraging influenza vaccination vs. standard pre-appointment reminder not mentioning influenza vaccination)
Detailed description
This trial is taking place in Los Angeles, CA among patients from primary care practices within the UCLA Health System, using 2x2x2 factorial design, nested in a parallel 2-arm trial. Sub-optimal vaccination rates are a significant problem in the U.S., despite their effectiveness in preventing morbidity and mortality from vaccine-preventable illness. For influenza specifically, annual epidemics of influenza cause substantial morbidity in the U.S. with up to 40,00-80,000 deaths/year and many hospitalizations, emergency and outpatient visits, and significant costs. Reminder/recall (R/R) messages, sent by phone, mail or other modality, can improve child and adult influenza vaccination rates. However, the majority of pediatric or adult primary care practices to not conduct R/R. Barriers are lack of finances, personnel, and algorithms to identify eligible patients. A technological breakthrough that might overcome these barriers involves patient portals-- secure, web-based communication systems, embedded within electronic health records (EHRs), for patients and providers to communicate with each other via email and the internet. Portals are used by about half of Americans and half of UCLA patients. This randomized controlled trial will assess the effectiveness of reminders messages, encouraging influenza vaccination, sent to patient portal users on increasing influenza vaccination rates within a health system by randomizing patients to two groups: 1) two-thirds of patients will receive reminder letters, 2) one-third will not receive reminders. Patients in the reminder arm will be further randomized (separately) for three additional components: 1) direct appointment scheduling, 2) pre-commitment prompts and 3) pre-appointment reminders. Direct scheduling: The convenience of scheduling an appointment for influenza vaccination may increase the likelihood that patients receive an influenza vaccination. Patients receiving reminders will be randomized to receive one of two types of reminder letters: 1) one half will receive flu vaccine reminder letters with a link to the MyChart direct appointment scheduling page and 2) one half will receive flu vaccine reminder message without the direct appointment scheduling link. Pre-commitment: Another potential influence on the decision to vaccinate is pre-commitment. Previous studies suggest that, upon being prompted, indicating an intention to do something increases the likelihood of following through. Patients will be randomized to one of two groups: 1) one half will receive pre-commitment prompt at the beginning of influenza vaccination season and 2) one half will not receive a pre-commitment prompt. The pre-commitment prompt asks whether the patient intends to receive influenza vaccine, and where and when they plan to get the vaccine. Pre-appointment flu reminders: Finally, a missed opportunities for vaccination occurs when patients are eligible for vaccination but are not offered a vaccine at their medical appointment. Pre-appointment reminders, sent in advance of an upcoming appointment, encouraging the patient talk to their doctor about influenza vaccination, may increase the likelihood of that patient receiving a vaccine. Patients will be randomized to one of two groups: 1) one half will receive modified pre-appointment reminders that mention influenza vaccination and 2) one half will receive the standard pre-appointment reminders for an upcoming appointment (no mention of influenza vaccination).
Interventions
Patients receive reminder/recall messages via the patient portal to get an influenza vaccination that include a direct scheduling link, enabling the patient to directly schedule a flu vaccination only visit
Patients receive reminder/recall messages via the patient portal to get an influenza vaccination (no direct scheduling link included)
Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination
Patients receive modified pre-appointment reminders for upcoming scheduled appointments that include language encouraging patients to ask the provider for the flu vaccine
Sponsors
Study design
Intervention model description
A 2x2x2 factorial design, nested within a parallel 2-arm trial.
Eligibility
Inclusion criteria
A patient within the UCLA Health System identified as a primary care patient per an internal algorithm.
Exclusion criteria
A patient within the UCLA Health System not identified as a primary care patient per an internal algorithm
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Index Patients Who Received Annual Influenza Vaccine | 6 months | Receipt of the annual influenza vaccination (between 8/1/20 - 4/1/21) among index patients. Outcomes will be assessed via vaccine data extraction from the electronic health record and external claims and pharmacy data. The index patients must also be an active UCLA Health MyChart user (\>= 1 login over the last 12 months from 8/1/20, excluding activity on the user's initial profile activation date). Individuals not affiliated with any primary care practice will be excluded from the primary analysis. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Direct Scheduling + Pre-commitment + Pre-appt Reminder Participants receive 1) reminder/recall messages regarding influenza vaccination via the patient portal with a link enabling direct scheduling, 2) a pre-commitment prompt and 3) pre-appointment reminders that mention asking the provider for a flu vaccine
Portal Reminders for Influenza Vaccination: Direct scheduling link: Patients receive reminder/recall messages via the patient portal to get an influenza vaccination that include a direct scheduling link, enabling the patient to directly schedule a flu vaccination only visit
Pre-Commitment Prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination
Pre-Appointment flu vaccine reminders: Patients receive modified pre-appointment reminders for upcoming scheduled appointments that include language encouraging patients to ask the provider for the flu vaccine | 17,848 |
| Direct Scheduling + Pre-commitment Participants receive 1) reminder/recall messages regarding influenza vaccination via the patient portal with a link enabling direct scheduling and 2) a pre-commitment prompt
Portal Reminders for Influenza Vaccination: Direct scheduling link: Patients receive reminder/recall messages via the patient portal to get an influenza vaccination that include a direct scheduling link, enabling the patient to directly schedule a flu vaccination only visit
Pre-Commitment Prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination | 17,842 |
| Direct Scheduling + Pre-appt Reminder Participants receive 1) reminder/recall messages regarding influenza vaccination via the patient portal with a link enabling direct scheduling and 2) pre-appointment reminders that mention asking the provider for a flu vaccine
Portal Reminders for Influenza Vaccination: Direct scheduling link: Patients receive reminder/recall messages via the patient portal to get an influenza vaccination that include a direct scheduling link, enabling the patient to directly schedule a flu vaccination only visit
Pre-Appointment flu vaccine reminders: Patients receive modified pre-appointment reminders for upcoming scheduled appointments that include language encouraging patients to ask the provider for the flu vaccine | 17,832 |
| Direct Scheduling Participants receive 1) reminder/recall messages regarding influenza vaccination via the patient portal with a link enabling direct scheduling
Portal Reminders for Influenza Vaccination: Direct scheduling link: Patients receive reminder/recall messages via the patient portal to get an influenza vaccination that include a direct scheduling link, enabling the patient to directly schedule a flu vaccination only visit | 17,827 |
| No Direct Scheduling + Pre-commitment + Pre-Appt Reminder Participants receive 1) reminder/recall messages regarding influenza vaccination via the patient portal without a link enabling direct scheduling, 2) a pre-commitment prompt and 3) pre-appointment reminders that mention asking the provider for a flu vaccine
Portal Reminders for Influenza Vaccination: No direct scheduling link: Patients receive reminder/recall messages via the patient portal to get an influenza vaccination (no direct scheduling link included)
Pre-Commitment Prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination
Pre-Appointment flu vaccine reminders: Patients receive modified pre-appointment reminders for upcoming scheduled appointments that include language encouraging patients to ask the provider for the flu vaccine | 17,821 |
| No Direct Scheduling + Pre-commitment Participants receive 1) reminder/recall messages regarding influenza vaccination via the patient portal without a link enabling direct scheduling and 2) a pre-commitment prompt
Portal Reminders for Influenza Vaccination: No direct scheduling link: Patients receive reminder/recall messages via the patient portal to get an influenza vaccination (no direct scheduling link included)
Pre-Commitment Prompt: Patients receive a pre-commitment prompt asking about their intention to get an influenza vaccination | 17,819 |
| No Direct Scheduling + Pre-appt Reminder Participants receive 1) reminder/recall messages regarding influenza vaccination via the patient portal without a link enabling direct scheduling and 2) pre-appointment reminders that mention asking the provider for a flu vaccine
Portal Reminders for Influenza Vaccination: No direct scheduling link: Patients receive reminder/recall messages via the patient portal to get an influenza vaccination (no direct scheduling link included)
Pre-Appointment flu vaccine reminders: Patients receive modified pre-appointment reminders for upcoming scheduled appointments that include language encouraging patients to ask the provider for the flu vaccine | 17,812 |
| No Direct Scheduling Participants receive 1) reminder/recall messages regarding influenza vaccination via the patient portal without a link enabling direct scheduling for a flu vaccine appointment
Portal Reminders for Influenza Vaccination: No direct scheduling link: Patients receive reminder/recall messages via the patient portal to get an influenza vaccination (no direct scheduling link included) | 17,805 |
| Control Arm Participants will not receive any reminder/recall messages regarding influenza vaccination via the patient portal or other intervention components | 71,167 |
| Total | 213,773 |
Baseline characteristics
| Characteristic | Direct Scheduling + Pre-commitment + Pre-appt Reminder | Direct Scheduling + Pre-commitment | Direct Scheduling + Pre-appt Reminder | Direct Scheduling | No Direct Scheduling + Pre-commitment + Pre-Appt Reminder | No Direct Scheduling + Pre-commitment | No Direct Scheduling + Pre-appt Reminder | No Direct Scheduling | Control Arm | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Age, Customized 18-64 years | 13166 Participants | 13234 Participants | 13208 Participants | 13202 Participants | 13274 Participants | 13148 Participants | 13238 Participants | 13122 Participants | 52973 Participants | 158565 Participants |
| Age, Customized <18 years | 1556 Participants | 1561 Participants | 1535 Participants | 1547 Participants | 1511 Participants | 1535 Participants | 1546 Participants | 1576 Participants | 6071 Participants | 18438 Participants |
| Age, Customized 65+ years | 3126 Participants | 3047 Participants | 3089 Participants | 3078 Participants | 3036 Participants | 3136 Participants | 3028 Participants | 3107 Participants | 12123 Participants | 36770 Participants |
| Primary Insurance Class Commercial | 12407 Participants | 12544 Participants | 12458 Participants | 12393 Participants | 12562 Participants | 12443 Participants | 12581 Participants | 12367 Participants | 49916 Participants | 149671 Participants |
| Primary Insurance Class Group Health Plan | 42 Participants | 38 Participants | 27 Participants | 37 Participants | 36 Participants | 49 Participants | 31 Participants | 42 Participants | 160 Participants | 462 Participants |
| Primary Insurance Class International Payor | 5 Participants | 4 Participants | 3 Participants | 3 Participants | 4 Participants | 5 Participants | 6 Participants | 5 Participants | 12 Participants | 47 Participants |
| Primary Insurance Class Medi-Cal | 280 Participants | 261 Participants | 270 Participants | 260 Participants | 247 Participants | 265 Participants | 263 Participants | 242 Participants | 1063 Participants | 3151 Participants |
| Primary Insurance Class Medicare | 2055 Participants | 1938 Participants | 2040 Participants | 2025 Participants | 1950 Participants | 2023 Participants | 1967 Participants | 2043 Participants | 7949 Participants | 23990 Participants |
| Primary Insurance Class Other | 223 Participants | 216 Participants | 217 Participants | 195 Participants | 220 Participants | 197 Participants | 190 Participants | 226 Participants | 888 Participants | 2572 Participants |
| Primary Insurance Class Package Billing | 1 Participants | 0 Participants | 1 Participants | 0 Participants | 0 Participants | 1 Participants | 1 Participants | 1 Participants | 0 Participants | 5 Participants |
| Primary Insurance Class Self-pay | 3 Participants | 2 Participants | 1 Participants | 2 Participants | 1 Participants | 2 Participants | 1 Participants | 3 Participants | 5 Participants | 20 Participants |
| Primary Insurance Class Tricare | 108 Participants | 106 Participants | 123 Participants | 121 Participants | 125 Participants | 120 Participants | 109 Participants | 117 Participants | 475 Participants | 1404 Participants |
| Primary Insurance Class UCLA Managed Care | 2688 Participants | 2700 Participants | 2662 Participants | 2760 Participants | 2648 Participants | 2683 Participants | 2623 Participants | 2723 Participants | 10566 Participants | 32053 Participants |
| Primary Insurance Class Unknown | 36 Participants | 33 Participants | 30 Participants | 31 Participants | 28 Participants | 31 Participants | 40 Participants | 36 Participants | 133 Participants | 398 Participants |
| Primary Language English | 17504 Participants | 17518 Participants | 17521 Participants | 17522 Participants | 17451 Participants | 17420 Participants | 17451 Participants | 17448 Participants | 69771 Participants | 209606 Participants |
| Primary Language Other | 192 Participants | 180 Participants | 166 Participants | 171 Participants | 231 Participants | 227 Participants | 198 Participants | 188 Participants | 800 Participants | 2353 Participants |
| Primary Language Spanish | 134 Participants | 133 Participants | 135 Participants | 122 Participants | 130 Participants | 157 Participants | 145 Participants | 155 Participants | 525 Participants | 1636 Participants |
| Primary Language Uknown | 18 Participants | 11 Participants | 10 Participants | 12 Participants | 9 Participants | 15 Participants | 18 Participants | 14 Participants | 71 Participants | 178 Participants |
| Race/Ethnicity, Customized American Indian or Alaska Native | 49 Participants | 53 Participants | 43 Participants | 46 Participants | 43 Participants | 34 Participants | 41 Participants | 47 Participants | 127 Participants | 483 Participants |
| Race/Ethnicity, Customized Asian | 1638 Participants | 1756 Participants | 1713 Participants | 1703 Participants | 1713 Participants | 1793 Participants | 1677 Participants | 1770 Participants | 6750 Participants | 20513 Participants |
| Race/Ethnicity, Customized Black | 826 Participants | 814 Participants | 821 Participants | 849 Participants | 837 Participants | 811 Participants | 787 Participants | 829 Participants | 3332 Participants | 9906 Participants |
| Race/Ethnicity, Customized Hispanic or Latino | 1802 Participants | 1840 Participants | 1828 Participants | 1877 Participants | 1894 Participants | 1857 Participants | 1883 Participants | 1868 Participants | 7400 Participants | 22249 Participants |
| Race/Ethnicity, Customized Multiracial | 526 Participants | 527 Participants | 500 Participants | 517 Participants | 522 Participants | 539 Participants | 476 Participants | 494 Participants | 2022 Participants | 6123 Participants |
| Race/Ethnicity, Customized Not Hispanic or Latino | 13227 Participants | 13081 Participants | 13272 Participants | 13271 Participants | 13164 Participants | 13235 Participants | 13111 Participants | 13221 Participants | 52663 Participants | 158245 Participants |
| Race/Ethnicity, Customized Other | 2449 Participants | 2491 Participants | 2456 Participants | 2472 Participants | 2475 Participants | 2439 Participants | 2509 Participants | 2465 Participants | 9796 Participants | 29552 Participants |
| Race/Ethnicity, Customized Unknown | 2620 Participants | 2677 Participants | 2597 Participants | 2534 Participants | 2637 Participants | 2528 Participants | 2686 Participants | 2540 Participants | 10406 Participants | 33279 Participants |
| Race/Ethnicity, Customized White or Caucasian | 9705 Participants | 9501 Participants | 9662 Participants | 9676 Participants | 9557 Participants | 9648 Participants | 9602 Participants | 9628 Participants | 38560 Participants | 115539 Participants |
| Sex/Gender, Customized Female | 10100 Participants | 10130 Participants | 10158 Participants | 10028 Participants | 10179 Participants | 10169 Participants | 10116 Participants | 10190 Participants | 40517 Participants | 121587 Participants |
| Sex/Gender, Customized Male | 7748 Participants | 7711 Participants | 7674 Participants | 7797 Participants | 7642 Participants | 7648 Participants | 7696 Participants | 7615 Participants | 30646 Participants | 92177 Participants |
| Sex/Gender, Customized Other | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 1 Participants | 1 Participants |
| Sex/Gender, Customized Unknown | 0 Participants | 1 Participants | 0 Participants | 2 Participants | 0 Participants | 2 Participants | 0 Participants | 0 Participants | 3 Participants | 8 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk | EG004 affected / at risk | EG005 affected / at risk | EG006 affected / at risk | EG007 affected / at risk | EG008 affected / at risk |
|---|---|---|---|---|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 |
| other Total, other adverse events | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 |
| serious Total, serious adverse events | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 | 0 / 0 |
Outcome results
Number of Index Patients Who Received Annual Influenza Vaccine
Receipt of the annual influenza vaccination (between 8/1/20 - 4/1/21) among index patients. Outcomes will be assessed via vaccine data extraction from the electronic health record and external claims and pharmacy data. The index patients must also be an active UCLA Health MyChart user (\>= 1 login over the last 12 months from 8/1/20, excluding activity on the user's initial profile activation date). Individuals not affiliated with any primary care practice will be excluded from the primary analysis.
Time frame: 6 months
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| Direct Scheduling + Pre-commitment + Pre-appt Reminder | Number of Index Patients Who Received Annual Influenza Vaccine | 6982 Participants |
| Direct Scheduling + Pre-commitment | Number of Index Patients Who Received Annual Influenza Vaccine | 6988 Participants |
| Direct Scheduling + Pre-appt Reminder | Number of Index Patients Who Received Annual Influenza Vaccine | 6920 Participants |
| Direct Scheduling | Number of Index Patients Who Received Annual Influenza Vaccine | 6990 Participants |
| No Direct Scheduling + Pre-commitment + Pre-Appt Reminder | Number of Index Patients Who Received Annual Influenza Vaccine | 7002 Participants |
| No Direct Scheduling + Pre-commitment | Number of Index Patients Who Received Annual Influenza Vaccine | 6999 Participants |
| No Direct Scheduling + Pre-appt Reminder | Number of Index Patients Who Received Annual Influenza Vaccine | 6945 Participants |
| No Direct Scheduling | Number of Index Patients Who Received Annual Influenza Vaccine | 6891 Participants |
| Control Arm | Number of Index Patients Who Received Annual Influenza Vaccine | 27645 Participants |