Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04532814

Enrollment

Registered

2020-08-31

Start date

2020-09-06

Completion date

2027-05-31

Last updated

2026-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Upper Body Obesity

Brief summary

The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.

Interventions

OTHERExercise

Cycling 60% VO2 max

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Intervention model description

This study is aimed to determine whether obesity effects muscle glucose utilization during exercise.

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

For the exercise studies of leg glucose uptake - "insulin sensitive" group: * Sedentary, normal weight, premenopausal women. * Sedentary, age-matched normal weight men. * Weight stable for two (2) months prior to study. * Willing to provide written, informed consent. * For the exercise studies of leg glucose uptake - "insulin resistant" group: For the exercise studies of leg glucose uptake - "insulin resistant" group: * Upper body obese (UBO) premenopausal women. * Age-matched upper body obese (UBO) men. * Weight stable for two (2) months prior to study. * Willing to provide written, informed consent.

Exclusion criteria

* Age \< 18 or \> 55 years (premenopausal women and age-matched men). * Use of glucose-lowering agents. * For female subjects: positive pregnancy test at the time of enrollment or study * History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy. * Active systemic illness or malignancy. * Symptomatic macrovascular or microvascular disease.

Design outcomes

Primary

Measure	Time frame	Description
Skeletal muscle glucose uptake	1 hour	Is exercise induced skeletal muscle glucose uptake different in obese compared to lean adults

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORMichael D Jensen, MD

Mayo Clinic

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 16, 2026