Morality, Morbidity;Newborn
Conditions
Keywords
Very preterm infant, Quality improvement, Mortality, Morbidities
Brief summary
A multicenter interventional study using evidence-based collaborative quality improvement to reduce mortality and major morbidities of very preterm infants in six neonatal centers in Shanghai
Detailed description
A multicenter interventional study using evidence-based collaborative quality improvement to reduce mortality and major morbidities of very preterm infants using evidence-based collaborative quality improvement interventions including benchmarking, potential better practice list, PDSA implementation and collaborative learning.
Interventions
BEHAVIORALEvidence-based collaborative quality improvement
Evidence-based collaborative quality improvement interventions including benchmarking, potential better practice list, PDSA implementation and collaborative learning
Sponsors
Shanghai Children's Medical Center
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Obstetrics & Gynecology Hospital of Fudan University
Shanghai First Maternity and Infant Hospital
Children's Hospital of Fudan University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 120 Days
Healthy volunteers
No
Inclusion criteria
1. Infants born at \>=24+0 weeks' gestation and \<32+0 weeks' gestation; 2. Admitted to the participating NICUs within 7 days after birth during study period
Exclusion criteria
1. Infants with major congenital anomalies; 2. Infants who transferred to non-participating hospitals within 24 hours after birth;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality or any major morbidity | During first NICU hospitalization (about 1-4 months) | It is a binary varibale (1/0). The variabel would be setted into 1,if death or with any of the following major morbidities: bronchopulmonary dysplasia, necrotizing stage II or above, retinopathy of prematurity stage III or above, intraventricular hemorrhage grade III or above or cystic periventricular leukomalacia and late-onset epsis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bronchopulmonary dysplasia | During first NICU hospitalization (about 1-4 months) | It is a binary varibale (1/0). The variabel would be setted into 1,if patients reveived respiratory support or oxygen at 36 weeks' corrected gestational age or on discharge |
| Necrotizing enterocolitis | During first NICU hospitalization (about 1-4 months) | It is a binary varibale (1/0). The variabel would be setted into 1,if patients appeared with NEC stage II or above |
| Severe brain injury | During first NICU hospitalization (about 1-4 months) | It is a binary varibale (1/0). The variabel would be setted into 1,if patients appeared with intraventricular hemorrhage grade III or above within 28 days after birth or cystic periventricular leukomalacia |
| Mortality | During the procedure (about 1-4 months) | It is a binary varibale (1/0). The variabel would be setted into 1,if patients dead during hospitalization or 28 days after discharge against medical advice |
| Late-onset sepsis | During first NICU hospitalization (about 1-4 months) | It is a binary varibale (1/0). The variabel would be setted into 1,if patients appeared with culture-proven sepsis after 72 hours after birth |
| Length of NICU stay | During first NICU hospitalization (about 1-4 months) | days for the first NICU hospitalization |
| Retinopathy of prematurity | During first NICU hospitalization (about 1-4 months) | It is a binary varibale (1/0). The variabel would be setted into 1,if patients appeared with ROP stage III or above. |
Countries
China
Outcome results
None listed