Epilepsy
Conditions
Brief summary
This research study will investigate the fluid from the area of the brain that is being removed during clinical epilepsy surgery. The goal is to analyze this fluid for inflammatory markers that can potentially help identify new strategies in the future to control seizures in individuals with epilepsy who fail to respond to currently available drugs.
Interventions
PROCEDUREIntraoperative brain microdialysis
Our current standard practice is to use a lateral approach through the middle temporal gyrus to place 3 depth electrodes targeting the hippocampus for intraoperative verification of pathological epileptiform activity prior to resection. Our research protocol will add one FDA approved electrode that has a central cannula for insertion of a microdialysis probe.
Sponsors
Mayo Clinic
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
We will establish intraoperative microdialysis in patients undergoing anterior temporal lobectomy for drug-resistant temporal lobe epilepsy. The human measurements will yield hypothesis-generating data and establish a methodological/logistical paradigm for future large-scale application of microdialysis in patients with drug refractory epilepsy.
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Failure to respond to at least two trials of anti-seizure drugs with different mechanisms of action * Normal MRI
Exclusion criteria
* Active immunomodulatory therapy * Autoimmune disorder * Signs or symptoms consistent with comorbid infection * Oncological comorbidity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection of analytes/protein | Through study completion, up to 5 years | Presence of protein in the microdialysate |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORCharles Howe, PhD
Mayo Clinic
Outcome results
None listed