Cirrhosis, Liver, Critical Illness
Conditions
Brief summary
The study aims to demonstrate the relationship between intra-abdominal hypertension (IAH) and abundant microaspirations in mechanically ventilated cirrhotic.
Detailed description
Intra-abdominal pressure monitoring will be performed using intra-vesical pressure every 8 hour in the first 2 days of mechanical ventilation. Micro aspiration is defined by pepsin or amylase positivity in trachea suction. Two groups will be compared : one with IAH , one without IAH.
Interventions
None listed
Sponsors
University Hospital, Lille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* adult patients * Cirrhosis * intubation and mechanical ventilation
Exclusion criteria
* pregnancy * oliguric patients * impossibility to measure intravesical pressure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| abundant microaspiration | 48 hours after inclusion | presence of pepsin or alpha amylase at significant level in at least 30% of tracheal aspirates |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | from ICU admission until day 28 | number of death |
| Incidence of ventilator associated pneumonia (VAP) | from intubation until day 28 or extubation | percentage of patients with VAP |
| duration of mechanical ventilation | from intubation until day 28 or extubation | number of days with mechanical ventilation |
| incidence of patients requiring renal replacement therapy | from ICU admission until Day 28 or ICu discharge, whichever came first | percentage of patients with renal replacement treatment |
| incidence of cirrhosis related complications | from ICU admission until Day 28 or ICU discharge, whichever came first | percentage of patients with cirrhosis related complications |
Countries
France
Contacts
Primary ContactSaad Nseir, MD,PhD
Outcome results
None listed