Androgen Receptor Gene Overexpression, Covid19
Conditions
Keywords
androgen receptor, severity, mortality
Brief summary
This research study will evaluate the association of Androgen Receptor (AR) gene expression and COVID-19 disease severity and mortality. The research procedure involves collection of a single saliva sample which will be mailed to the participants by the study team. This saliva will be used in a COVID-19 Androgen Sensitivity Test (CoVAST) which will detect AR gene expression. Eligible participants are males, at least 18 years or older, and have tested positive for COVID-19.
Interventions
GENETICCOVID-19 Androgen Sensitivity Test (CoVAST)
The CoVAST Test is an in-vitro non diagnostic test. The test reports the genetic health risk of male patients in developing severe symptoms following COVID 19 infection. The genetic information provided by this test will help physicians evaluate the association of AR gene polymorphism with disease severity and mortality following COVID-19 infection. The CoVAST Test is indicated for reporting of the following variant associated with the following gene.
Sponsors
Applied Biology, Inc.
University of California, Irvine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Male over the age of 18 * Laboratory confirmed SARS-CoV-2 infection * Able to give verbal informed consent
Exclusion criteria
* Unable to give informed consent * Diagnosed with an additional respiratory co-infection * XXY males
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients deceased | 28 days | Number of subjects deceased at or before 28 days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients discharged | 14 days | Number of patients discharged at or before 14 days |
Countries
United States
Outcome results
None listed