Sepsis
Conditions
Brief summary
Observational study for monitoring of capillary refill time in sepsis
Detailed description
This is an observational studying assessing changes in capillary refill time over the course of sepsis treatment.
Interventions
DEVICECapillary Refill Assessment
Device to quantify capillary refill time
Sponsors
Oregon Health and Science University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. Clinical evidence of a known or suspected infection and orders written for administration of IV antibiotics 2. Hypotension as defined by the need for any vasopressor (and 1 liter of fluid already administered) OR respiratory failure defined by assisted ventilation (includes mechanical ventilation and BIPAP), CPAP, or greater than or equal to 6 liters/minute of supplemental oxygen
Exclusion criteria
1. No consent/inability to obtain consent from the participant or a legally authorized representative 2. Diagnosis of cirrhosis by medical chart review 3. Liver transplant recipient 4. AST or ALT greater than five times upper limit of normal 5. Diagnosis of ongoing chronic alcohol use disorder/abuse by chart review; if medical record unclear, use Appendix F 6. Clinical diagnosis of diabetic ketoacidosis or other condition such as profound hypoglycemia that requires hourly blood glucose monitoring 7. Hypersensitivity to Acetaminophen or Vitamin C 8. Patient, surrogate or physician not committed to full support (Exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest) 9. Home assisted ventilation (via tracheotomy or noninvasive) except for CPAP/BIPAP used only for sleep-disordered breathing 10. Current active kidney stone 11. Known history of oxalate kidney stones or history of oxalate nephropathy 12. Kidney transplant recipient 13. Use of home oxygen for chronic cardiopulmonary disease 14. Moribund patient not expected to survive 24 hours 15. Underlying malignancy or other condition with estimated life expectancy of less than 1 month 16. Pregnant woman, woman of childbearing potential without a documented negative urine or serum pregnancy test during the current hospitalization, or woman who is breast feeding 17. Prisoner 18. Enrollment in another critical care based pharmacologic interventional trial 19. Treating team unwilling to enroll because of intended use of Acetaminophen or Vitamin C
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood lactate Level | during procedure | Correlation of Capillary refill to blood lactate |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vasoactive | 24 hours | Correlation of capillary refill to need for vasoactive medications |
| 28 day hospital mortality | 28 days | Correlation of initial capillary refill time to 28 day hospital mortality |
Countries
United States
Outcome results
None listed