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The Research About Acute Compartment Syndrome

Acute Compartment Syndrome

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04529330
Enrollment
80
Registered
2020-08-27
Start date
2019-01-01
Completion date
2030-12-31
Last updated
2021-08-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Compartment Syndrome

Keywords

ACS, Tibial plateau fractures, Tibial shaft fractures

Brief summary

Acute compartment syndrome (ACS) is defined as a clinical entity originated from trauma or other conditions, and remains challenging to diagnose and treat effectively. Threre is the controversy in diagnosing, treating ACS. It was found that there was no criterion about the ACS, and result unnecessary osteotomy. The presence of clinical assessment (5P) always means the necrosis of muscles and was the most serious or irreversible stage of ACS. Besides pressure methods, the threshold of pressure identifying ACS was also controversial.

Interventions

PROCEDUREfasciotomy

if it was suspected with ACS, the fasciotomy was conducted. but if the blister observed, it means decreased conmpartment sydrome. therefore, the blister observed can avoid unnecessary fasciotomy to patients suspected with ACS

Sponsors

Hebei Medical University Third Hospital
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum

Inclusion criteria

* Fracture patients with Schatzker V and VI, * Who were older than eighteen years.

Exclusion criteria

* The

Design outcomes

Primary

MeasureTime frameDescription
blister skin immunochemistry and immunofluorescence analysisthrough study completion, an average of 1 yearCK1, 5, 10, claudin 1, 2 and occludin as determined by immunochemistry analysis, and skin barrier proteins; claudin 1, 2 and occludin was determined by immunofluorescence analysis and qPCR.
union timethrough study completion, an average of 1 yearThe relative data was collected about union time
No non-anatomic gap or step (larger than 5 mm)through study completion, an average of 1 yearThe relative data was collected about complications
secondary loss of reductionthrough study completion, an average of 1 yearThe relative data was collected about complications
Deep venous thrombosisthrough study completion, an average of 1 yearThe relative data was collected about complications
superficial wound problemsthrough study completion, an average of 1 yearThe relative data was collected about complications
injury mechanismup to 1 weeksThe relative data was collected about injury mechanism such as high falling accident, traffic accident, fall from standing height,Crushing
the time when the blister appearedup to 4 weeksThe relative data was collected about the time when the blister appeared after injury
time to reconstructive surgerytime to when the surgery was conducted after 2 weeksThe relative data was collected about time to reconstructive surgery

Secondary

MeasureTime frameDescription
CK levelsthrough hospitalization completion, an average of 1 monthCK levels
chloride levelsthrough hospitalization completion, an average of 1 monthchloride levels
UREA levelsthrough hospitalization completion, an average of 1 monthUREA levels

Other

MeasureTime frameDescription
VAS scoresthrough study completion, an average of 1 yearvisual analogue scale
LKS scorethrough study completion, an average of 1 yearLysholm knee score

Countries

China

Contacts

Primary ContactGuo Jialiang, Doctor
drjlguo86@gmail.com18203222090
Backup ContactMa Lijie, Doctor

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026