Anosmia, Covid19
Conditions
Brief summary
Time to recover of Anosmia and / or ageusia and early corticosteroid use
Detailed description
In a study of dexamethasone kinetics in two groups of 15 patients with community-acquired pneumonia, one group was treated with dexamethasone 6 mg/day by mouth and the other with 4 mg/day intravenously. The apparent volume of distribution was 1 L/kg in both groups, but the half-life after oral administration was approximately 7 hours, and after intravenous administration 9 hours. The bioavailability of oral dexamethasone was 81% (95% CI = 54-121%). However, the biological half-life of dexamethasone is much longer, of the order of 36-54 h compared with 18-36 h for prednisolone. Time to recover of Anosmia and / or ageusia and early corticosteroid use
Interventions
DRUGEarly-Dexamethasone
early use of dexamethasone as early as laboratory evidence of high inflammatory markers
DRUGLate dexamethazone
Use of dexamethasone on deterioration of the cases with increased severity
Sponsors
ClinAmygate
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Any case with COVID-19 * Age more than or equal to 18 years * Mild to moderate severity
Exclusion criteria
* Diabetes * Any contra-indication for the interventional drug * Mentally disabled cases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to recovery | one to 6 weeks | Time to recovery from anosmia and / or agusia |
Countries
Egypt
Contacts
Primary ContactEmad R Issak, MD
Outcome results
None listed