Infections and Colonization With the Third Group of Enterobacteriaceae in the Intensive Care Unit

Infections and Colonization With the Third Group of Enterobacteriaceae in the Intensive Care Impact on the Mortality and Morbidity

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04528043

Acronym

EB3REA

Enrollment

179

Registered

2020-08-27

Start date

2017-04-01

Completion date

2019-12-31

Last updated

2020-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antibiotic Resistant Infection, Critically Ill, Enterobacteriaceae Infections

Keywords

Third group Enterobacteriaceae, infection, colonization, resistance, AMPc cephalosporinase

Brief summary

There is a lack of data whether colonization and infection with Enterobacteriaceae of the third group (EB3) affect the outcomes for ICU patients. This study evaluated the effects of EB3 colonization and infection on ICU mortality, ICU length of stay (LOS) and broad-spectrum antibiotic exposure. We focused on the sub type Enterobacter regarding its a priori higher risk of resistance.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* adults critically ill patients admitted to the the participating ICUs during the study period * with colonization and/or infection with a third group enterobacteriacea * and with a lenght of stay \> 24h

Exclusion criteria

* minors patients * lenght of stay \< 24h

Design outcomes

Primary

Measure	Time frame	Description
all cause mortality	Day 180	Evaluation of the impact of colonization and/or infection with third group enterobacteriaceae on mortality during hospitalization and up to 180 day

Secondary

Measure	Time frame	Description
Resistance strains of sub type enterobacter	DAY 90	Evaluation of number of resistant strains among Enterobacter subtype in comparison with other third group enterobacteriaceae

Countries

France

Outcome results