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Neuromuscular Ultrasonography Utility for Detection of Peripheral Neuropathy in Systemic Lupus Erythematosus

Neuromuscular Ultrasonography Utility for Detection of Peripheral Neuropathy in Systemic Lupus Erythematosus

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04527172
Enrollment
55
Registered
2020-08-26
Start date
2018-05-20
Completion date
2020-05-15
Last updated
2020-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral Neuropathy, System; Lupus Erythematosus

Keywords

Neuromuscular ultrasound, SLE, Peripheral neuropathy

Brief summary

This study aims to evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient and to correlate it to traditional neurophysiological studies, clinical signs and activity of SLE.

Detailed description

The frequency of SLE peripheral neuropathy documented by electrophysiology has been estimated to be approximately 30%. The term peripheral neuropathies include symmetric polyneuropathy, single and multiple mononeuropathy, and radiculopathy. There has been increasing interest in using ultrasonography (US) to aid peripheral neuropathy diagnosis and studies have shown good correlation with other imaging modalities. US is a non-invasive and inexpensive imaging device that has become widely available as a diagnostic tool at many fields. so systemic lupus patients were enrolled in the study , performed nerve conduction study and neuromuscular ultrasound for bil. median, ulnar, peroneal, tibial and sural nerves , on statistics the cross sections were compared in neurophusiologically affected and non affected nerves, also the sensitivity and specifity of NMUS in comparison to the traditional NCS was calculated

Interventions

ultrasound to visualize the peripheral nerves of lupus patients and to compare it with results of the raditional electrophysiological studies

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
17 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

1. All adult SLE patients who was admitted to Rheumatology & Rehabilitation department of Assuit university hospital during time frame of study. 2. apparently healthy subjects with normal electrophysiological study 3. verbal consent, free and informed

Exclusion criteria

* • Other causes of peripheral neuropathy: 1. Traumatic 2. Purely degenerative 3. Diabetic 4. Toxic 5. Infections 6. Drug induced

Design outcomes

Primary

MeasureTime frameDescription
evaluate the rule of NMUS in detection of peripheral neuropathy in SLE patient6monthsMeasuring sensitivity and specificity of neuromuscular ultrasound in comparison to nerve conduction study
Describing the patterns of peripheral nerve affection in SLE patient6monthsEvaluating different studied nerves clinically, electrophyiologically and by neuromuscular ultrasonography

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 15, 2026