COPD
Conditions
Brief summary
Patients with COPD that a pulmonologist classifies between Stage 1-2 in accordance with the GOLD criteria and age and gender-matched healthy individuals will be included in the study. In both groups (n = COPD: 17, Healthy: 17), aerobic exercise (AE) in the target heart rate range of 50% intensity, performed by cycling accompanied by blood flow restriction, will be applied.
Detailed description
Target heart rate will be calculated from the formula (Maximal heart rate-resting heart rate) x% desired intensity ratio + resting heart rate. The target occlusion amount in the lower extremity will be calculated by calculating 45% of the complete occlusion rates reported by Michael et al. The proximal border of the thigh cuffs will be tied in line with the gluteal lines on both sides. Exercise tolerance and dyspnea condition; Measurement properties in COPD will be evaluated using a well-defined modified Borg scale (MBS). Individuals will use any bronchodilator that their doctor sees fit before trying. The target aerobic exercise intensity will be reached in the last minute of the first five-minute warm-up period by maintaining a 4-6 feeling of dyspnea in the MBS, by increasing pedal resistance and speed. In case of extreme shortness of breath, exercise intensity will be reduced to resting heart rate. In the event of oxygen desaturation (85%) during the intervention, the intervention will be terminated. Aerobic exercise training protocol; It was planned as 50 rpm speed and warming up at the lowest pedal resistance during the first 4 minutes, reaching the target exercise intensity range in the next 1 minute, aerobic training at the target heart rate range and appropriate MBS value for the next 20 minutes, cooling down in the last 5 minutes. The duration will be reduced in case of excessive shortness of breath, fatigue and muscle pain due to increased exercise volume. The distance, calories, and maximum speed values measured during the study will be recorded. Before and immediately after the study, all participants had muscle damage (creatine kinase), anti-inflammatory response (CRP, neutrophil), oxidative stress response (uric acid, LDH), oxygen saturation, heart rate, systolic and diastolic pressure will be examined. Institution of the Study: Karabuk University Research Hospital Chest Diseases Clinic Center / Karabuk. The study would be conducted in the presence of a chest diseases specialist.
Interventions
Patients and healthy individuals will be given 30 minutes of aerobic exercise by cycling, by restricting lower extremity blood flow.
Sponsors
Medipol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
25 COPD patients were referred to the study from the pulmonology clinic of the hospital where the study was conducted by a medical secretary who was blinded to the intervention. In addition, 21 healthy individuals volunteered to participate in the study from the same hospital where the study was previously announced.
Intervention model description
Two groups will be formed as healthy and patient groups and the same treatment initiative will be applied.
Eligibility
Sex/Gender
MALE
Age
40 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* No drug change for at least 30 days for the COPD group * Not participating in a structured activity program for at least six months * Have the ability to cooperate
Exclusion criteria
* Presence of any pathology that limits physical activity performance * Presence of severe or unstable heart disease * Presence of peripheral artery disease * Being in an exacerbation period of the disease * Presence of another active disease (rheumatic, oncological, traumatic etc.) * Any neurological or orthopedic disease that prevents exercise
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| creatine kinase | 30 minutes | rhabdomyolysis marker |
| C reactive protein, neutrophil | 30 minutes | inflammatory marker |
| oxygen saturation | 30 minutes | blood oxygen saturation |
| heart rate | 30 minutes | determination of aerobic exercise dose |
| systolic and diastolic pressure | up to 18 weeks | to mean arterial pressure calculation |
| modified borg scale | up to 18 weeks. | dyspnoea measurement, Minimum 1, maximum 7 points are obtained. 5 indicates the best respiratory condition, 10 the worst respiratory condition. |
| oxidative stress markers | up to 18 weeks | uric acid, lactate dehydrogenase |
Countries
Turkey (Türkiye)
Outcome results
None listed