Gastroesophageal Varices, Myeloproliferative Neoplasm, Portal Caver Cavernoma, Portal Hypertension
Conditions
Keywords
portal hypertension, gastroesophageal varices, jak2 mutation, myeloproliferative Neoplasm, portal caver cavernoma
Brief summary
Myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis, may lead to gastroesophageal varices. The quality of life, morbidity, and mortality of MPN patients mainly depend on disease-related symptoms, thromboembolic and hemorrhagic complications. Previous studies have shown that JAK2 V617F has a prominent role in vascular risk and MPN-associated gastroesophageal varices. Portal vein thrombosis and portal cavernoma frequently occur in the MPN population and the management of gastroesophageal varices in these patients are sometimes technically difficult. The aim of this study is to investigate the the characteristics of patients with gastroesophageal varices and portal caver cavernoma with or without JAK2 mutation.
Interventions
DIAGNOSTIC_TESTJAK2 mutation test
Patients with portal caver cavernoma will be divided into two groups by the result of JAK2 mutation test
Sponsors
Shanghai Zhongshan Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Inclusion criteria
* male or female patients aged 18-75 * diagnosed as portal hypertension and portal cavernoma by contrast-enhanced computed tomography * underwent JAK2 mutation test
Exclusion criteria
* combined known etiologies of chronic liver disease, including hepatitis, primary biliary cirrhosis, schistosomiasis, and non-alcoholic fatty liver disease. * other factors judged by the investigator that may affect the safety of the subject or the compliance of the trial. Such as serious illnesses (including mental illness) that require combined treatment, serious laboratory abnormalities, or other family or social factors.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| History of variceal bleeding | 1 day (the same time as diagnosis) | Have a history of the occurrence of gastroesophageal variceal bleeding |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 1-year death rate | 1 year | 1-year death rate |
| Complications of portal hypertension | 1 year | The concurrence of complications of portal hypertension (ascites, infections, variceal bleeding, et al) |
Countries
China
Outcome results
None listed