Acute Kidney Injury, Acute-On-Chronic Liver Failure
Conditions
Brief summary
Acute kidney injury (AKI) is one of the most important factors associated with increased mortality in patients with acute-on-chronic liver failure (AoCLF). Early identification and treatment of this subgroup of patients may improve survival and decrease ICU length of stay. As kidney ischemia is one of the main mechanisms responsible for AKI in AoCLF, an increase in urinary to arterial partial pressure of oxygen may help in the early diagnosis of renal failure. For this arterial and urinary oxygen pressure will be measured at ICU admission, on day 1 and day 3 of ICU stay. Diagnosis of AKI within the first 28 days after ICU admission will be recorded
Interventions
None listed
Sponsors
Institutul Clinic Fundeni
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- patients admitted to the ICU for acute-on-chronic liver failure
Exclusion criteria
* pre-existing renal disease * urine output\<200 mL/day * death within the first 24 hours after ICU admission * emergency liver transplantation within the follow-up period (28 days)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| AKI | 28 days after ICU admission | incidence (%) of AKI in patients with AoCLF as defined by Acute Kidney Injury Network guidelines |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| arterial to urinary oxygen gradient | ICU admission, ICU day 1 and ICU dy 3 | mathematical difference in oxygen partial pressure between arterial blood and urine (mmHg) in patients with AKI compared to patients without AKI |
| mortality | 28-days | 28-day mortality |
Countries
Romania
Contacts
Primary ContactDana Tomescu, Prof
Backup ContactMihai Popescu, Assoc Prof
Outcome results
None listed