Brain Injuries, Traumatic
Conditions
Keywords
Brain Injuries, Early Goal-directed Sedation
Brief summary
EGDS management strategy was implemented in ICU patients with severe brain injury, the depth of sedation and GCS score were monitored, and the protective effects of EGDS strategy and standard sedation strategy on the brain of patients with severe brain injury were discussed.
Interventions
OTHEREarly goal-directed sedation programs
A. Provide sedation at the beginning of the titration of dextrometomidine; b. Optimize sedation when dextrometomidine is used alone and at a maximum dose not sufficient to provide comfort and safety to the patient and to achieve a level of sedation at any time specified by the treating physician. C. Provides immediate recovery and sedation, and can control sudden agitation at any time
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of severe craniocerebral injury * The GCS score is 6 to 12 points * Within 12 hours of intubation * The mechanical ventilation time is greater than 24 hours * Obtain written consent
Exclusion criteria
* Pregnant women * Acute liver failure * Dementia or mental illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Richmond Agitation-Sedation Scale | through study completion, an average of 2 year |
| Mechanical ventilation time | through study completion, an average of 2 year |
| length of stay in ICU | through study completion, an average of 2 year |
Secondary
| Measure | Time frame |
|---|---|
| complication | through study completion, an average of 2 year |
Outcome results
None listed