Oral Lichen Planus, Thyroid Diseases
Conditions
Keywords
oral lichen planus, thyroid diseases
Brief summary
Thyroid disease is a common endocrine disorder. Oral lichen planus (OLP) is a chronic autoimmune disease that occurs on the oral mucosa in 1-2% of the general population.The purpose of this study was to determine whether there is an association between thyroid disease and oral planus lichen in the population of our patients. In the last few years, a couple of studies have been published in the world literature that have studied the possible association of these diagnoses in different populations. Most of the results showed a higher prevalence of thyroid disease in the population of lichen patients, compared with patients without lichen, although some results are contradictory. Some authors believe that the onset of OLP precedes thyroid dysfunction. In the population of Croatian patients with lichen, no research has been done to study the possible connection between these two diseases. The obtained results could help clarify whether there is a connection between these two diagnoses in the population of our lichen patients and enable earlier detection of patients with thyroid hypofunction.
Interventions
DIAGNOSTIC_TESTdetermination of thyroid hormones and antibodies
TSH, fT3, fT4, anti-TPO and anti-Tg were determined from blood sample
Sponsors
University of Zagreb
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* for test group: female patients of the Department of Oral Medicine School of Dental Medicine University of Zagreb with clinically and histopathologically confirmed oral lichen planus * for control group: female patients of the Department of Oral Medicine School of Dental Medicine University of Zagreb, without oral lichen planus or other immune disorders; age matched to test group
Exclusion criteria
* male patients; female patients with immune disorders; female patients which are not age-matched to test group
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The prevalence of thyroid diseases in patients with oral lichen planus | January 2020-April 2020 | to determine whether there is a higher prevalence of thyroid disease in patients with oral lichen |
Countries
Croatia
Outcome results
None listed