Increased CRP Concentrations in Patients Admitted to the Emergency Department With Troponin Elevation Aids to Rule Out Coronary Ischemia

Increased C-reactive Protein Concentrations in Patients Admitted to the Emergency Department With Troponin Level Elevations Aids to Rule Out Coronary Ischemia

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04522583

Enrollment

15000

Registered

2020-08-21

Start date

2020-09-30

Completion date

2021-03-31

Last updated

2020-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Ischemia

Brief summary

The investigators hypothesized that the CRP/troponin ratio measured in patients presenting to the ED with elevated troponin levels could differentiate between patients with cardiac ischemia and those who present due to a systemic inflammatory or infectious disease. The aim of the study was to determine the necessary CRP/troponin ratio required to rule out cardiac ischemia in a large ED population and determine its impact on long-term prognosis.

Interventions

DIAGNOSTIC_TESTDiagnosis of Myocardial Ischemia

Discharge diagnosis of myocardial ischemia

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* All patients admitted to the ED in the period 2016-2019 with cTn level higher than the 99th percentile of cTn concentration in the normal population (\>0.014 nanogram/milliliter).

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame	Description
Accuracy of the CRP/Troponin ratio	Within 6 months	The accuracy of the CRP/Troponin ratio in ruling out of myocardial ischemia according to the diagnosis of ischemia/coronary intervention at discharge analyzed by standard statistical measures

Countries

Israel

Contacts

Primary ContactSimcha R Meisel, MD, MSC

meisel.simcha@gmail.com972-52-3260931

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026