Oesophageal Atresia, Dumping Syndrome
Conditions
Keywords
Oesophageal dysmotility, Oesophageal atresia, Post prandial hypoglycaemia, Gastric emptying troubles
Brief summary
Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood. This is also an affection difficult to diagnose, because it only occurs after meals and can be inconstantly present. To date, their is only symptomatic treatment for DS. This study aims to understand its pathological mechanisms so as to better treat it and avoid its consequences. Oesophageal atresia patients enrolled in this study will benefit from a continuous glycemic monitoring, a continuous cardiac monitoring, and an a gastric emptying scintigraphy at the age of 3 months
Interventions
DEVICEGlycemic Holter
Continuous glycaemia monitoring,
RADIATIONgastric emptying scintigraphy
Fasting administration of a Technecium-labelled milk bottle and quantification of the remaining radioactivity by a camera every 30 minutes for 4 hours.
DEVICEHolter ECG
continuous cardiac monitoring
Sponsors
Groupement Interrégional de Recherche Clinique et d'Innovation
french patient association for oesophageal atresia AFAO
University Hospital, Lille
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Months to 3 Months
Healthy volunteers
No
Inclusion criteria
* Patients operated at birth for Oesophageal atresia type C * Aged from 2 to 3 months at inclusion * Off prokinetic treatment (suspended for at least 72 hours) before monitoring
Exclusion criteria
* History of dumping syndrome of other cause (microgastria, fundoplication, dysautonomia..) * History of any disease that can modify glycemic regulation (hyperinsulinism, neonatal diabete) * Treatment that can modify gastric motility
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Abnormal glycaemia associated with vagal hypertonia | At least once during the 48 hours monitoring | Composite criteria: association between abnormal glycaemia (high or low) and variations of cardiac frequency |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Abnormal glycaemia associated with abnormal gastric emptying | At least once during the 48 hours monitoring | Composite criteria: association between abnormal glycaemia (high or low) and abnormal gastric emptying study |
| Persistance of dumping syndrome | At the age of 6 months | measured by a gastric emptying scintigraphy |
| Tolerance of glucose monitoring | At least once during the 48 hours monitoring | Occurrence of side effects or technical issues during monitoring |
Countries
France
Contacts
Primary ContactMadelaine AUMAR, MD
Outcome results
None listed