Healthy Aging, Healthy Diet
Conditions
Brief summary
To evaluate the acute effects of respiratory muscle exercises vs. a control intervention on blood glucose kinetics in healthy adults after an oral glucose tolerance test.
Interventions
OTHER5min respiratory muscle exercises
5 min of hyperpnea at a target intensity of 60-80% MVV 15-30min after ingestion of 75g of glucose
OTHER15min respiratory muscle exercises
5 min of hyperpnea at a target intensity of 60-70% MVV 15-30min after ingestion of 75g of glucose
Sponsors
Swiss Federal Institute of Technology
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
NONE
Intervention model description
This study consists of four visits to the laboratory, each separated by at least 24 hours and each lasting approximately 2.5h. Total duration for each participant is approximately 2 weeks. The study is conducted in 40 healthy adults (≥ 18 years). The study is a randomized, controlled cross-over trial. We chose a cross-over design in order to test the effects of different respiratory exercises compared to a control intervention in order to minimize variability since each subject serves as his/her own control. Due to the nature of the intervention (respiratory muscle exercises), it is not possible to blind participants to the interventions.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age ≥18 years * Healthy * Non-smoking * Body mass index (BMI): 18.5 - 29.9 kg∙m-2 * Normal lung function * Willing to adhere to study rules
Exclusion criteria
* Known or suspected non-compliance, drug or alcohol abuse * Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant * Previous enrolment into the current study * Intake of medications affecting metabolism, the cardiovascular or the respiratory system, or sleep * Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep * Pregnancy, breastfeeding, or intention to become pregnant during the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Peak blood glucose concentration | throughout the study, an expected average of 2 weeks per participant | Peak blood glucose concentration will be determined in the three conditions (5min or 15min respiratory muscle exercises or control). |
| area under the glucose-time curve | throughout the study, an expected average of 2 weeks per participant | Area under the glucose-time curve will be determined in the three conditions (5min or 15min respiratory muscle exercises or control). |
Countries
Switzerland
Outcome results
None listed