Propofol Overdose of Undetermined Intent
Conditions
Brief summary
The induction dose of propofol is generally determined based on patients' characteristics, underlying disease, general condition, and also by clinician's experiences. However, It is difficult to anticipate and objectively calculate an adequate dose of propofol for every patient considering the variability of an individual's response to propofol. If there is a specific pattern in EEG prior to induction of anesthesia that can provide information about the patient's susceptibility to propofol, every induction may be performed far more smoothly with a precisely optimized dose of propofol for each patient. The study is to find a relationship between the pre-induction EEG pattern of adult patients and their sensitivity to propofol.
Interventions
DRUGPropofol
The dose of propofol required for loss of consciousness and the total induction dose of propofol will be recorded for every patients.
DEVICEEEG monitoring
The processed EEG spectrogram and indices, such as patient status index, 95% spectral edge frequency, and suppression ratio, will be obtained from Sedline monitoring device. The raw pre-induction EEG will be extracted from Sedline at the end of induction and it will be analyzed by an external software to calculate the mean frequency, frequency band power and its distribution.
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 89 Years
Healthy volunteers
No
Inclusion criteria
* Adult patients undergoing general anesthesia
Exclusion criteria
* Patients undergoing cardiac or brain surgery * Patients with neurological deficit or impaired communication (Glasgow Coma Scale \< 15) * Unstable vital sign (cardiogenic, hemorrhagic, septic shock) * Patients with eclampsia * Patients who administered preoperative anxiolytics * Patients who do not require intubation * Patients who are considered unsuitable for the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Absolute and Relative power in distinct frequency (% δ: 1-4 Hz, % θ: 5-8 Hz, % α: 9-12 Hz, % β: 13-25 Hz) | During the induction of anesthesia (up to 15 min) | Relative power in distinct frequency (% δ: 1-4 Hz, % θ: 5-8 Hz, % α: 9-12 Hz, % β: 13-25 Hz) |
| Processed EEG index (PSI; patient state index) | During the induction of anesthesia (up to 15 min) | Processed EEG index (PSI; patient state index) |
| Mean frequency and 95% spectral edge frequency (Hz) | During the induction of anesthesia (up to 15 min) | Mean frequency and 95% spectral edge frequency (Hz) |
| Burst suppression ratio (%) | During the induction of anesthesia (up to 15 min) | Burst suppression ratio (%) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vital sign - blood pressure | During the induction of anesthesia (up to 15 min) | Check blood pressure (mmHg) |
| The effect-site concentrations of propofol at loss of consciousness (μg/ml) | During the induction of anesthesia (up to 15 min) | The effect-site concentrations of propofol at loss of consciousness (μg/ml) |
| Administration of vasopressors (ephedrine, phenylephrine, epinephrine, etc) | During the induction of anesthesia (up to 15 min) | Administration of vasopressors (ephedrine (mg), phenylephrine (mcg), epinephrine (mcg), etc) |
| Vital sign - heart rate | During the induction of anesthesia (up to 15 min) | Check heart rate (beats per minute) |
| The dose of propofol required for loss of consciousness (mg) | During the induction of anesthesia (up to 15 min) | The dose of propofol required for loss of consciousness (mg) |
| Total amount of propofol used (mg) | During the induction of anesthesia (up to 15 min) | Total amount of propofol used (mg) |
| Time to loss of consciousness (second) | During the induction of anesthesia (up to 15 min) | Time to loss of consciousness (second) after the start of induction |
Countries
South Korea
Outcome results
None listed