Transpulmonary Pressure Measurements in Intubated Children With Covid-19 Respiratory Failure

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04519411

Enrollment

Registered

2020-08-19

Start date

2020-05-21

Completion date

2022-12-31

Last updated

2023-02-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID 19

Brief summary

The purpose of this study is to gather information to help doctors understand how Covid-19 affects the lungs in children.

Interventions

DIAGNOSTIC_TESTTranspulmonary pressure measurements

Transpulmonary pressure measurements

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

No minimum to 17 Years

Healthy volunteers

Inclusion criteria

* Patients 0-17 years of age, 10 kg or greater, with suspected or confirmed Covid-19 respiratory failure requiring endotracheal intubation and mechanical ventilation admitted to Mayo Clinic Hospital, St. Mary's Campus Pediatric Intensive Care Unit.

Exclusion criteria

* Patients \<10 kg * Patients with pre-existing chronic mechanical ventilation (chronic respiratory failure) * Patients with known esophageal disease (strictures, known esophageal anatomic abnormalities) * Patients with severe coagulopathy (for which placement of esophageal balloon or other gastric tube via nose or mouth is contraindicated) * Patients who are pregnant (as determined by standard pregnancy testing criteria for Pediatric ICU admission).

Design outcomes

Primary

Measure	Time frame	Description
Transpulmonary pressure	Through study complication, usually 2 weeks	Numerical data

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026