Epilepsy
Conditions
Brief summary
Epilepsy is a chronic brain disease with recurrent seizures and the comorbidity of psychiatric diseases are very common. The prevalence of depression in patients with refractory epilepsy is about 60%. However, the early diagnosis is usually difficult due to the unclear mechanism and untypical clinical symptoms, and there are no extremely effective treatments for depression in patients with epilepsy until now. In this prospective, multi-center, cohort study, we aim to investigate and screen two different types of depression (cognitive and somatic) in patients with epilepsy by using the combination of regular moods evaluating scales and heart rate variability instrument. The intervening methods of combining transcranial direct current stimulation (tDCS) and serotonin re-uptake inhibitors (SSRIs) are used to treat the patients with comorbidity of epilepsy and depression.
Detailed description
Epilepsy is a chronic brain disease with recurrent seizures and the comorbidity of psychiatric diseases are very common. The prevalence of depression in patients with refractory epilepsy is about 60%. However, the early diagnosis is usually difficult due to the unclear mechanism and untypical clinical symptoms, and there are no extremely effective treatments for depression in patients with epilepsy until now. In this prospective, multi-center, cohort study, we aim to investigate and screen two different types of depression (cognitive and somatic) in patients with epilepsy by using the combination of regular moods evaluating scales and heart rate variability instrument. The intervening methods of combining transcranial direct current stimulation (tDCS) and serotonin re-uptake inhibitors (SSRIs) are used to treat the patients with comorbidity of epilepsy and depression. And resting-state functional MRI will be conducted in patients with the comorbidity of epilepsy and depression before and after the combing treatment of tDCS and SSRIs.
Interventions
OTHERpsychology therapy
If the symptoms are mild, patients will get the psychology therapy. If it's necessary according to patients' willings, patients will be given SSRIs antidepressant therapy.
Sponsors
Huashan Hospital
Ruijin Hospital
Shanghai 10th People's Hospital
Shanghai 6th People's Hospital
Shanghai East Hospital
Shanghai Zhongshan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* meeting the definition of epilepsy according to the new definition issued by ILAE in 2014 * not using antidepressants * acquiring informed consents
Exclusion criteria
* patients with severe psychiatric symptoms; * progressive brain diseases * malignant tumors * severe cognitive declines
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the rate of seizure frequency | 12 months | epilepsy diary |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the quality of life | 12 months | scale |
Countries
China
Outcome results
None listed