Aged, Colorectal Neoplasms
Conditions
Keywords
Delirium, Pain, Postoperative, Dexmedetomidine, Transversus abdominis plane block
Brief summary
To compare the prognosis of elderly patients undergoing radical resection of colorectal cancer treated with general anesthesia and general anesthesia combined with transversus abdominis plane block and continuous infusion of dexmedetomidine. The incidence of postoperative delirium, postoperative acute pain moderately to severely and poor postoperative recovery were composite endpoints to determine the prognosis of patients.
Interventions
DRUGDexmedetomidine
After finished the transversus abdominis plane block, then perform tracheal intubation and start the infusion of dexmedetomidine.
PROCEDURETransversus abdominis plane block using ropivacaine
Before anesthesia, the ultrasound-guided bilateral transversus abdominis plane block using 0.25% ropivacaine was perdormed by anesthesiologist who is not involved in intraoperative management and postoperative follow-up and evaluate the effect after the block completed.
PROCEDURETransversus abdominis plane block using saline
Before anesthesia, the ultrasound-guided bilateral transversus abdominis plane block using saline was perdormed by anesthesiologist who is not involved in intraoperative management and postoperative follow-up and evaluate the effect after the block completed.
DRUGSaline
After finished the transversus abdominis plane block, then perform tracheal intubation and start the infusion of saline, dosage and infusion method of saline are consistent with dexmedetomidine.
Sponsors
Beijing Tiantan Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Aged 65-80 years,regardless of gender * American Society of Anesthesiologists physical status I-III * Undergoing elective radical resection of colorectal cancer * Sign informed consent
Exclusion criteria
* Could not cooperate to complete the pain VAS evaluation * Could not cooperate to complete the cognitive function assessment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The prognosis of aged patients | Postoperative 72 hours | The incidence of postoperative delirium, postoperative acute pain moderately to severely and poor postoperative recovery were composite endpoints to determine the prognosis of patients. |
Countries
China
Outcome results
None listed