Sarcopenia, Chronic Kidney Diseases, Osteoporosis
Conditions
Keywords
Fall, Chronic kidney disease-mineral and bone disorder (CKD-MBD)
Brief summary
This study is a cross-sectional study that wishes to investigate whether there is an increased incidence of sarcopenia in patients with chronic kidney disease compared to the Danish background population. A possible association between sarcopenia and fall, as well as the incidence of osteoporosis in patients with chronic kidney disease will also be described.
Detailed description
Sarcopenia is a condition diagnosed from different clinical findings such as low muscle mass, low muscle strength and possibly also poor physical performance. In the general population, the risk of fall and bone fracture increases, when sarcopenia is also present. Sarcopenia is known to occur in patients with chronic kidney disease, but whether, and if so, how this differs from the incidence in patients without kidney disease has not previously been described. Patients with chronic kidney disease have a 3 times higher risk of bone fracture compared to the Danish background population, and they also have an increased risk of falls. The association between sarcopenia, risk of falls and osteoporosis in patients with kidney disease is until now sparsely described, and because of this, the investigators want to explore this further in this cross-sectional study.
Interventions
DIAGNOSTIC_TESTDXA
Each participant will undergo one DXA scan
OTHERMuscle strength and function assessment
Each patient will have their muscle strength and function assessed with the measurements of handgrip strength, 10 m gait speed and a 30 s sit-to-stand test. They will also fill out a questionnaire assessing Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls (SARC-F questionnaire).
OTHERBlood samples
Each patient will undergo a physical examination and also deliver blood samples.
Sponsors
Odense University Hospital
Herlev Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 120 Years
Inclusion criteria
* Age ≥20 years * Chronic kidney disease stage 4-5 not on dialysis (nonD) (corresponding to an estimated glomerular filtration rate (eGFR) ≤30 ml/min based on Kidney Disease Improving Global Outcomes (KDIGO) definition and not on dialysis)
Exclusion criteria
* Kidney transplanted * Immobilized/hospitalized for more than 1 week within the last 6 weeks * Active treatment with growth hormone or sex hormone * Known muscle disease * The lack of ability to speak or understand Danish * The lack of ability to give an informed consent * The lack of ability to participate in a clinical study based on the assessment by the local investigator
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in appendicular lean body mass | Day 0 (day of study procedure) | Difference in appendicular lean body mass between patients with chronic kidney disease and a healthy control group examined in a previous study |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference in appendicular muscle mass | Day 0 (day of study procedure) | Difference in appendicular muscle mass between patients with chronic kidney disease and a healthy control group examined in a previous study |
| Difference in handgrip strength | Day 0 (day of study procedure) | Difference in handgrip strength between patients with chronic kidney disease and a healthy control group examined in a previous study |
| Difference in gait speed | Day 0 (day of study procedure) | Difference in gait speed between patients with chronic kidney disease and a healthy control group examined in a previous study |
| Difference in the incidence of sarcopenia | Day 0 (day of study procedure) | Difference in the incidence of sarcopenia between patients with chronic kidney disease and a healthy control group examined in a previous study |
| Difference in the incidence of osteoporosis | Day 0 (day of study procedure) | Difference in the incidence of osteoporoses between patients with chronic kidney disease and a healthy control group examined in a previous study |
| Difference in the tendency to fall | Day 0 (day of study procedure) | Difference in the tendency to fall between patients with chronic kidney disease and a healthy control group examined in a previous study |
| The correlation between total lean and appendicular lean body mass, handgrip strength, gait speed, sit-to-stand test, tendency to fall and osteoporosis | Day 0 (day of study procedure) | The correlation between total lean and appendicular lean body mass, handgrip strength, gait speed, sit-to-stand test, tendency to fall and osteoporosis (T-score \<-2.5 in hip and/or lumbal spine) |
| Difference in sit-to-stand test | Day 0 (day of study procedure) | Difference in sit-to-stand test between patients with chronic kidney disease and a healthy control group examined in a previous study |
Countries
Denmark
Contacts
Primary ContactSabina C Hauge, MD
Backup ContactDitte Hansen, MD, PhD
Outcome results
None listed