Covid19, Pregnancy, Infections in
Conditions
Keywords
COVID-19, Pregnancy, Complete blood count, Perinatal outcome, Monocyte/lymphocyte ratio (MLR)
Brief summary
Complete blood count parameters are routinely evaluated cost-effective markers in diagnosis and clinical follow-up of infectious diseases.There is increasing number of studies to report the course of COVID-19 in pregnancy. The current study aimed to elucidate the changes in hematologic parameters in response to SARS-CoV-2 infection and whether there was an increase in adverse perinatal outcomes such as increased neonatal intensive care unit admission and lower APGAR scores in pregnancies with COVID-19.
Detailed description
The objective of this study is to evaluate the relationship between Coronavirus Disease 2019 (COVID-19) in pregnancy and adverse perinatal outcomes. The secondary aim is to analyze the diagnostic value of hematologic parameters in COVID-19 complicated pregnancies.The current study is conducted in a high volume tertiary obstetrics center burdened by COVID-19 pandemics, in Turkey, between March 20 and July 25, 2020. The study included a pregnant women cohort who had been regularly followed up and delivered in our clinics. The cohort was divided into two groups to reveal the impact of COVID-19 on the complete blood count cell indices and unfavorable obstetric and early neonatal outcomes in pregnant women. The clinically confirmed diagnosis of COVID-19 cases were included in Study Group (n=39) the healthy pregnant women without COVID-19 were included in Control Group (n=69). The study achieved a power of 0.89 and 0.98 with a 5% level of significance.
Interventions
OTHERClinical assessment
Perinatal outcomes and diagnostic value of hematologic parameters were compared between pregnancies with and without COVID-19.
Sponsors
Ankara City Hospital Bilkent
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 42 Years
Healthy volunteers
Yes
Inclusion criteria
* Spontaneous pregnancy, * Singleton pregnancy, * Clinically diagnosed COVID-19 (SARS-CoV-2 positivity in real time-polymerase chain reaction)
Exclusion criteria
* Chronic maternal diseases (rheumatological diseases, renal failure, vascular malformations, hypertension, cardiac disease, diabetes mellitus, obesity, hypo-hyperthyroidism, congenital hematological disorders), * Acute inflammatory conditions (acute pancreatitis, acute appendicitis), * Pregnancy complications (gestational diabetes, PPROM, preeclampsia), * Multiple pregnancies, * Anticoagulant medication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| complete blood count parameters (including the number of lymphocytes, Leukocytes, monocytes, platelets and red blood cells). | first 1 hour of hospitalization. | cell count per mm3. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| APGAR score | 5 minutes | 1st and 5th minute newborn assessment |
| maternal and newborn length | 5 minutes | centimeters |
| maternal and newborn weight | 2 minutes | kilograms |
| body temperature | 2 minutes | Celsius degree |
Countries
Turkey (Türkiye)
Outcome results
None listed