Postoperative Nausea and Vomiting
Conditions
Keywords
postoperative nausea and vomiting, heart rate variability, propofol, sevoflurane
Brief summary
Propofol and sevoflurane have different effects on heart rate variability. It has not yet been reported whether this difference in effect remains at recovery time after anesthesia and the difference is related to postoperative nausea and vomiting has not been studied. The aim of this study is observe whether propofol and sevoflurane have different effects on heart rate variability during recovery and the differences can predict the occurrence of postoperative nausea and vomiting.
Detailed description
Different types of anesthetics have different effects on heart rate variability. However It has not yet been reported whether this difference in effect remains at recovery time after anesthesia. Several studies have been reported that preoperative heart rate variability predicted the occurence of postoperative nausea and vomiting. However, whether the difference in heart rate variability after anesthesia is related to the difference in postoperative nausea and vomiting has not been studied. Therefore, this study aims to observe whether propofol and sevoflurane have differences during recovery period after anesthesia in heart rate variabiliy. In addition, we want to examine that these differences during recovery period in heart rate variability can predict the occurrence of nausea and vomiting within 24 hours after surgery.
Interventions
DRUGPropofol
General anesthesia using propofol infusion
DRUGSevoflurane
General anesthesia using sevoflurane
Sponsors
Ajou University School of Medicine
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Scheduled breast surgery under general anesthesia
Exclusion criteria
* Arrhythmia * Uncooperative with the measuring heart rate variability * Diabetes * Hypertension on medication * Patients taking psychiatric drugs * Thyroid disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| heart rate variability in recovery room | within 1 hour | Postoperative heart rate variability measuring at recovery room Frequency domain result: total power, low frequency power, high frequency power, Low frequency/high frequency power ratio |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative nausea vomiting impact scale | 48 hours after anesthesia | Q1. Have you vomited or had dry-retching? 0. No 1. Once 2. twice 3. 3 or more times Q2. Have you experienced a feeling of nausea? If yes, has your feeling of nausea interfered with activities of daily living? 0. not at all 1. Sometimes 2. often or most of the time 3. All of the time Add the numerical responses to questions 1 and 2. (total score 0\ 6) |
| The incidence of postoperative nausea and vomiting | 48 hours after anesthesia | the time of occurence |
| Patient's satisfaction about postoperative nausea and vomiting | 48 hours after anesthesia | verbal rating scale (0\ 10), 0=very unsatisfied, 10=very satisfied |
Countries
South Korea
Outcome results
None listed