Atrial Fibrillation, Cardiopulmonary Exercise Test, Rate Control
Conditions
Keywords
Atrial Fibrillation, rate control, cardiopulmonary exercise test
Brief summary
To search for the best marker for the patients in atrial fibrillation with rate control
Detailed description
In an aging society, the prevalence of atrial fibrillation is increasing. The main treatment strategy is to reduce the complications of embolic stroke and heart failure. Among these patients, a group of them will choose to have "rate control" based on the heart conditions and the preference of the patients. The strategy is to control the ventricular rate by drugs to prevent the heart from failure. However, when the physicians attempt to do so, they encounter two questions: how much is the optimal drug dose? And what is the best marker we are looking to? To answer these questions, the investigators design a prospective, cross-over study to explore this issue. The participants will do cardiopulmonary exercise test (CPET) before and after treatment. They will receive another CPET if drug dose is titrated up. With the study, the investigators will understand whether a resting heart rate can be a good marker for optimal drug dosage, and what is the optimal range of heart rate the physicians should target.
Interventions
DRUGAtenolol, Bisoprolol, Metoprolol, Nebivolol, Propranolol, Diltiazem, Verapamil, digoxin
Start with empirical lower dose for 3 months, and then titrate up
Sponsors
National Taiwan University Hospital
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
1. 18\~90 years old 2. Rate control is preferred after shared decision making
Exclusion criteria
1. cannot cooperate with or complete CPET 2. has contraindication for CPET, such as uncontrolled heart failure, hypertension, angina, valvular heart disease, lung function impariment that SaO2\<90% at room air. 3. Ventricular rate below 80/min before any medication 4. Permanent pacemaker implanted
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of Maximal Oxygen consumption | 0, 3, 6 months | acquire the data by Cardiopulmonary exercise test (CPET) with different (low and high) drug dosages for rate control |
Countries
Taiwan
Contacts
PRINCIPAL_INVESTIGATORChih-Chieh Yu, MD.PhD
National Taiwan University Hospital
Outcome results
None listed