Liver Failure, Acute
Conditions
Brief summary
Major liver surgery is associated with increased incidence of perioperative complications and increased mortality if these are not addressed quickly in a high dependency intensive care unit. Of these, posthepatectomy liver failure (PHLF) represents one of the most important cause of postoperative unfavourable outcome. The present study investigates the correlation between lactate levels and PHLF. Lactate levels were collected at six specific timepoints: preoperative, pre-dissection phase, post-dissection phase, end of surgery and 24-hours and 48-hours in the postoperative period.
Interventions
DIAGNOSTIC_TESTserum lactate
perioperative measurement of lactate levels
Sponsors
Institutul Clinic Fundeni
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients undergoing major liver surgery for primary or secondary tumours
Exclusion criteria
* unsigned patient consent * death within 24 hours * need for perioperative renal replacement therapy * underlying liver disease (e.g. liver cirrhosis) * other causes of raised lactate levels (e.g. shock)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| lactate levels (mmol/L) in patients with PHLF | early postoperative period (48 hours) | correlation of lactate levels with the diagnosis of PHLF |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mortality | 30 days mortality | in hospital mortality |
Countries
Romania
Outcome results
None listed