Anesthesia
Conditions
Brief summary
This study aim is to compare the effect of magnesium sulphate combined with low dose rocuronium versus standard dose rocuronium
Detailed description
Comparing the effect of magnesium sulphate combined to low dose rocuronium versus standard dose rocuronium in cancer patients undergoing direct laryngoscopy for laryngeal tumors regarding intubating conditions, intraoperative relaxation, depth of anesthesia and recovery time.
Interventions
DRUGstandard rocuronium dose
0.6 mg/kg rocuronium during induction of anesthesia
DRUGMagnesium sulfate
50 mg/kg magnesium sulphate added to 0.40 mg/kg rocuronium
Sponsors
National Cancer Institute, Egypt
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
Patients with Laryngeal tumors ASA I-II Age 30-70 years
Exclusion criteria
Renal and or hepatic insufficiency Neuromuscular disease Large glottic and/or supra-glottic lesions with or without breathing difficulties Known allergy to any of the used drug
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Onset and duration of muscle relaxant | 90 minutes | Onset time of muscle relaxant and duration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Degree of muscle relaxation | 90 minutes | depth of blockade |
Countries
Egypt
Outcome results
None listed