Covid19
Conditions
Keywords
COVID19
Brief summary
The global escalation of COVID19 pandemic has put the health care system under pressure with urgent need for treatment. In the absence of vaccine and approved drug against SARS-COV2 over the past 6 months, the health authorities were obliged to re-purpose existing drugs to fight this pandemic.
Detailed description
Ivermectin is a well-known FDA-approved pan antiparasitic drug with high safety profile and potential therapeutic effects against COVID 19. It has been previously investigated as an antiviral agent. It showed 5000 fold reduction of SARS COV 2 viral RNA in-vitro studies. However, some researchers questioned its efficacy in the oral form as very high doses will be required to achieve a proper tissue concentration and viricidal effect in the respiratory system. Our hypothesis is that, since COVID-19 has shown to be particularly damaging to the respiratory system, using inhaled forms of Ivermectin will deliver the drug directly to the infection site and make it a treatment option.
Interventions
DRUGIvermectin nasal
Ivermectin nasal spray one ml in each nostril two times daily
DRUGIvermectin oral
Ivermectin oral (one tablet 6 mg three times daily)
OTHERstandard care
oxygen via masks or ventilators
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* mild to moderate severity who are confirmed to be positive for SARS COV 2.
Exclusion criteria
* patients with severe form of COVID-19 or those who are on ventilatory support or those with cytokine storm
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PCR of SARS-Cov2 RNA | 14 days | Negative PCR result of SARS-Cov2 RNA in COVID19 patients |
Contacts
Primary ContactKamal Okasha, PhD
Backup ContactNahla El-Ashmawy, PhD
Outcome results
None listed