Covid19, Post-Op Complication, Surgery
Conditions
Brief summary
Observational study to determine the optimal timing for surgery following SARS-CoV-2 infection and assess key global surgery indicators.
Detailed description
* Prospective, observational international cohort study. * Any hospital worldwide can participate (including hospitals that have not admitted SARS-CoV-2 infected patients). * All patients undergoing a surgical procedure in an operating theatre will be included. All consecutive eligible patients should be included. * 7-day data collection period, with follow-up at 30 days after surgery for each patient. However, no changes should be made to normal patient care/ follow-up pathways * Primary outcome is 30-day mortality. * All collaborators will be included as PubMed-citable co-authors on resulting publications.
Interventions
None listed
Sponsors
National Institute for Health Research (NIHR) Global Health Research Unit Grant (NIHR 16.136.79)
Association of Coloproctology of Great Britain and Ireland
Bowel & Cancer Research
Association of Upper Gastrointestinal Surgeons; British Association of Surgical Oncology
Bowel Disease Research Foundation
British Gynaecological Cancer Society
European Society of Coloproctology
National Institute for Health Research, United Kingdom
Sarcoma UK
Vascular Society for Great Britain and Ireland
Yorkshire Cancer Research
University of Birmingham
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Any operation (elective or emergency) done in an operating theatre by a surgeon. * All surgical specialties including: acute care surgery, breast surgery, cardiac surgery, colorectal surgery, general surgery, gynaecology, hepatobiliary surgery, neurosurgery, obstetrics, oesophagogastric surgery, ophthalmology, oral and maxillofacial surgery, orthopaedics, otolaryngology, paediatric surgery, plastic surgery, thoracic surgery, transplant surgery, trauma surgery, urology, vascular surgery. * Day case surgery and inpatient surgery included. * Any SARS-CoV-2 status (positive at any time, negative, not tested). * All ages including children and adults.
Exclusion criteria
Minor procedures (full list will be available in the protocol).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-operative mortality | 30 days after surgery | Mortality at 30 days after surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| In-patient mortality | 30 days after surgery | Mortality while the patient is admitted to hospital |
| Post-operative pulmonary complications | 30 days after surgery | 30-day postoperative pulmonary complications (pneumonia \[CDC definition\], ARDS, unexpected ventilation) |
| Post-operative venous thromboembolism | 30 days after surgery | 30-day venous thromboembolism (deep vein thrombosis/ pulmonary embolism) |
| Post-operative complications | 30 days after surgery | 30-day Clavien-Dindo grade |
Contacts
Primary ContactAneel Bhangu, PhD
Backup ContactDmitri Nepogodiev, Master
Outcome results
None listed