Autoimmune Bullous Disease
Conditions
Keywords
ELS
Brief summary
The purpose of this study is to identify the presence or absence of ectopic lymph node-like structures in skin lesions of patients with autoimmune bullous disease and the subtypes of the cells deposited there. In addition, this study clarifies the therapeutic effect of intralesional steroid injection in patients with pemphigus harboring ectopic lymph node-like structure.
Interventions
PROCEDUREBiopsy
5\ 20mg/ml, intralesional injection every 1 month. Number of cycles: until the lesions are clinically cleared
Sponsors
Gangnam Severance Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\<Presence of Ectopic Lymphoid-like Structures in the Skin lesion of Autoimmune Bullous Disease Patients\> Prospective study Inclusion Criteria: 1. Adults over 19 2. Patietns who voluntarily signed the consent form 3. Patients who are diagnosed with autoimmune bullous disease through clinical, histological and serological tests Retrospective study Inclusion Criteria: 1. Samples in human-derived banks from March 2013 to October 2018 2. Patients who are diagnosed with autoimmune bullous disease through clinical, histological and serological tests 3. Adults over 19 \<Treatment of Ectopic Lymphoid-like Structures in the Skin lesion of Autoimmune Bullous Disease Patients\> Prospective study Inclusion Criteria: 1. Adults over 19 2. Patients who voluntarily signed the consent form 3. Patients who have skin lesions harboring ectopic lymph node-like structure in a prospective or retrospective manner 4. Patients who have chronic lesions sustained for more than 4 months during the treatment of systemic corticosteroids Retrospective study Inclusion Criteria: 1. Patients who have skin lesions harboring ectopic lymph node-like structure in a retrospective manner 2. Paitents who have been treated for intralesional steroid injection 3. Patients who have data of photography to compare the clinical effects before and after intralesional corticosteroid treatment.
Exclusion criteria
1\. Patients who do not meet the criteria for autoimmune bullous disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical outcome: size of lesions | through study completion, an average of 1 year | The area of the lesions will be measured using the Image J program |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The presence or absence of ectopic-lymph node-like structure by histologic evaluation | through study completion, an average of 1 year | The presence of absence of ectopic-lymph node-like structure will be evaluated by histologic evaluation |
Countries
South Korea
Outcome results
None listed