the Study Focus to Improve the Standard of Care Used for Aluminuim Phosphide Poisoning and to Save Patients With the Minimal Organ Damage
Conditions
Keywords
N-acetyl cysteine, Acety L- carnitine, paraffin oil, aluminium phosphide
Brief summary
Aluminium Phosphide is a pesticide used in developing countries to prevent rodents and pests from spoiling the harvested grains. it is presented as tablets which can be administered accidently to humans or for committing suicide. this pesticide is fatal even in small concentration as mortality rate can reach 75- 100% of cases. in this study researchers tried to add some supplements to the routine treatment to improve and decrease the fatality rate.
Interventions
DRUGN-acetyl cysteine
a drug which can have an off label use as an antidot for aluminium phosphide poisoning in addition to sodium bicarbonate and ondansetron as standard of care
DIETARY_SUPPLEMENTacetyl L-carnitine
Naturallu occuring amino acid derivative which can be taken as a dietary supplement involves in mitochondrial function and energy production and is suggested to have a role in lowering organ damage resulting from aluminium phosphide poisonong in addition to sodium bicarbonate and ondansetron as standard of care
DRUGmedicated paraffin oil
refined mixture of liquid hydrocarbons which used as laxative and is suggested to reduce absorption of aluminium phosphide if taken within two hours of administration of the toxin in addition to sodium bicarbonate and ondansetron as standard of care
standard of care for treatment of aluminuim phosphide is provided for patients poisoned with aluminuim phosphide
Sponsors
Ain Shams University
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All adult patients with history of acute intoxication with AlP presented to the Poison Control Center of Ain-Shams University hospitals during the period of the study
Exclusion criteria
1. Patients less than 18 2. Patients presented with delay time exceeding 12 hours after acute intoxication. 3. Patients with history of cardiac, renal or hepatic diseases. 4. Patients who show hypersensitivity to NAC, ALCAR or paraffin oil.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| mortality rate reduction | 1 year | the primary end point is to lower the mortality rate for patients poisoned with aluminium phosphide pellets |
| organ damage reduction | 1 year | another primary end point is to reduce organ damage and injury for survivors |
Countries
Egypt
Contacts
Primary ContactMahmoud Sakr, PhD
Backup ContactHanan Abdel Wahab, Master's
Outcome results
None listed