Covid19, Pulmonary Edema, Respiratory Distress Syndrome, Adult, Ventilation Perfusion Mismatch
Conditions
Keywords
ards, covid19
Brief summary
Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from typical Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.
Interventions
DEVICEExtravascular Lung Water Index
Measurement of the EVLWI
DEVICEPulmonary Vascular Permeability Index
Measurement of the PVPI
Sponsors
Istanbul University - Cerrahpasa
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ARDS defined by Berlin Criteria longer than 24 hours * Undergoing mechanical ventilation * Noradrenaline demand \>0.1 mcg/kg/min
Exclusion criteria
* Not meeting ARDS criteria * Noninvasive mechanical ventilation * ARDS resolved shorter than 24 hours * Shock resolved
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Extravascular Lung Water Index | 1 day | The amount of fluid accumulated in the lung measured by transpulmonary thermodilution (ml/kg) |
| Pulmonary vascular permeability index | 1 day | Integrity of the alveolocapillary barrier measured by transpulmonary thermodilution |
Countries
Turkey (Türkiye)
Outcome results
None listed