Critical Illness, Inspiratory Muscle Strength, Mechanical Ventilation, Respiratory Muscle Training
Conditions
Brief summary
Respiratory muscle weakness is common after mechanical ventilation and occurs early. This can limit functional recovery. Respiratory muscle training is often neglected in clinical practice. Some data indicates that inspiratory muscle training increases inspiratory muscle strength and quality of life. The aim of the study is to assess the impact of combined inspiratory and expiratory muscle training on inspiratory muscle strength. The second aim is to assess the impact of this training program on expiratory muscle strength.
Interventions
PROCEDUREinspiratory and expiratory muscle training
inspiratory muscle training using threshold IMT device expiratory muscle training using a bottle filled of water
PROCEDUREinspiratory and expiratory exercises
inspiratory exercise using fractionated inspirations expiratory exercise using a bottle filled with water at a minimum level
Sponsors
University of Liege
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Masking description
patients are masked: they will all benefit from respiratory physiotherapy, with placebo or real muscle training investigator and care providers are unmasked, as they set the training parameters
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient from mechanical ventilation after at least 24 hours of support * collaborative patient
Exclusion criteria
* confusion, mental disorder * not french speaking * pulmonary surgery in the past 12 months * external ventricular drain * previous pneumothorax or pneumothorax not drained * rib fractures * alveolar hemorrhage * hemodynamic instability * labial occlusion impossible (face burn, facial paralysis) * patient refusal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in inspiratory muscle strength | between 7 to 15 days after ICU discharge (compared to ICU discharge) | measurement of maximal inspiratory pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in expiratory muscle strength | between 7 to 15 days after ICU discharge (compared to ICU discharge) | measurement of maximal expiratory pressure |
| respiratory infections | 1 month after ICU discharge | number of respiratory infections requiring antibiotics after ICU discharge |
| change in dyspnea perception | 1 month after ICU discharge (compared to hospital discharge) | assessed using Dyspnea-12 questionnaire (score from 0 to 36, 36 indicating a maximal dyspnea) |
| impact of dyspnea on physical activities | between 7 to 15 days after ICU discharge | assessed using modified Medical Research Council (m-MRC) score: stage 0 to 4 (last stage indicating a patient too dyspneic to leave house or breathless when dressing) |
Countries
Belgium
Contacts
Primary ContactAnne-Françoise Rousseau, MD, PhD
Outcome results
None listed