Parkinson Disease, Sleep
Conditions
Keywords
glymphatic system, meditation
Brief summary
This involves development and application of magnetic resonance imaging (MRI) methods for visualizing hemodynamic and metabolic relationships in healthy volunteers with advanced meditation experience.
Detailed description
This study is evaluating the glymphatic system during awake, sleep, and meditative states.
Interventions
BEHAVIORALMeditation
meditation
Sponsors
Vanderbilt University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Masking description
no masking is used in this protocol
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Ages 14-45 * Adept meditator status
Exclusion criteria
* Any non-MR compatible material implant, or contraindication to MR scanning * Claustrophobia or inability to lie still for prolonged periods of time * Participants with a recent (less than 2 months) infection, tattoo, or wound * No consumption of stimulants or alcohol within 12 hours of the study visit * clinical diagnosis of any major neurological or psychological condition * Taking benzodiazepines, cholinestorase inhibitors, anti-psychotics, opioids, MAO inhibitors
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CSF flow change | baseline to 24 hours | Using MRI to assess the change in CSF flow in awake, sleep deprived, and meditative states |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| EEG changes | baseline to 24 hours | Looking at brain wave changes before and after intervention in Alpha, Beta, and Delta waves associated with light to deep sleep. The lowest bandwidth for alpha waves is 8 while the highest is 12. The lowest bandwidth for Beta waves is 13 Hz while the highest is 30 Hz. The lowest bandwidth for Delta waves is .4 Hz and the highest is 4 Hz. |
Countries
United States
Outcome results
None listed