Urolithiasis
Conditions
Brief summary
The aim of the study was to compare the ultrastructural changes in the renal parenchyma with the results of postprocessing CT analysis with contrast enhancement in patients with urolithiasis.
Interventions
PROCEDUREPercutaneous Nephrolithotomy
PCNL will be carried out in accordance with the standards and capabilities of the medical center. After the procedure pathomorphological data of the renal parenchyma will be assessed
PROCEDUREPartial nephrectomy
Partial nephrectomy will be carried out in accordance with the standards and capabilities of the medical center. After the procedure pathomorphological data of the renal parenchyma will be assessed
PROCEDURERadical nephrectomy
Nephrectomy will be carried out in accordance with the standards and capabilities of the medical center. After the procedure pathomorphological data of the renal parenchyma will be assessed
Sponsors
I.M. Sechenov First Moscow State Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
for experimental group: 1. Men and women \>18 years and \<45 years old; 2. Established diagnosis of urolithiasis that does not interfere with the processes of urodynamics (there is no expansion of the overlying urinary tract); 3. Planned surgery - percutaneous nephrolithotripsy; 4. Stone size up to 20 mm., Patients with multiple small two-sided stones; 5. Patients with CT of the kidneys with contrast enhancement performed according to the required protocol.
Exclusion criteria
for experimental group: 1. Age \< 18 years old or ASA\> 3; 2. With single kidney; 3. Patients with coral stones; 4. The presence of concomitant systemic pathology (DM, AH), as well as kidney disease (glomerulonephritis), which can change the state of the renal parenchyma; 5. A history of injuries and surgical interventions on the kidneys, urinary tract, renal vessels; 6. Taking nephrotropic drugs; 7. Systemic intake of nephrotoxic drugs; 8. Severe general somatic condition, making the operation impossible; 9. Pregnancy. Inclusion Criteria for control group: 1. Men and women \>18 years and \<45 years old; 2. Absence of urolithiasis in the patient's anamnesis and in his family history; 3. Renal tumors which have undergone partial nephrectomy or nephrectomy; 4. Patients with CT renal data with contrast enhancement, performed according to the required protocol.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To evaluate the features of interrenal transport of contrast agent and the structural state of the renal tissue | 1 month | The data of 3D analysis of CT of the kidneys in patients with urolithiasis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To assess the features of the morphological structure of glomeruli, tubules, perivascular and interstitial spaces of renal tissue in patients with urolithiasis | 2 weeks | The assessment will be based on intraoperative biopsy |
Countries
Russia
Contacts
Primary ContactDmitry Fiev, M.D., Ph.D.
Outcome results
None listed