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Stress & Social Cognition in Borderline Personality Disorder

Fight-or-flight Versus Tend-and-befriend Response to Behavioral and Pharmacological Interventions in Patients With Borderline Personality Disorder - Part I

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04504994
Acronym
SOKO-1
Enrollment
196
Registered
2020-08-07
Start date
2020-02-01
Completion date
2021-12-01
Last updated
2022-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Borderline Personality Disorder

Brief summary

The investigators will examine whether perceived social exclusion provoke a reduction in prosocial behavior in BPD patients.

Detailed description

The investigators will examine whether perceived social exclusion provoke a reduction in prosocial behavior, such as empathy, in BPD patients and whether this fight-or-flight pattern is also seen in other relevant aspects of social behavior, such as sharing and punishment behavior. To induce social exclusion all participants will play cyberball, either the exclusion condition or the (over)inclusion condition before testing

Interventions

BEHAVIORALinclusion condition

cyberball game: ex- versus over-inclusion condition

Sponsors

Charite University, Berlin, Germany
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

female patients with BPD and healthy control women, matched for age, body mass index, and education

Exclusion criteria

physical illness

Design outcomes

Primary

MeasureTime frameDescription
empathy30 minutes after cyberballMultifaceted Empathy Test

Secondary

MeasureTime frameDescription
sharing behavior: amount of monetary units (max 30) shared with co-playerdirectly after cyberballComputer game

Other

MeasureTime frameDescription
punishment behavior: number of accepted offers from co-player15 minutes after cyberballComputer game

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026