Abdominal Surgery, Lung Function, Postoperative Complications
Conditions
Keywords
Lung function, Diffusion capacity, Postoperative complications, Abdominal surgery
Brief summary
The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery. Inclusion: Patients undergoing surgery for abdominal surgery Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies. Investigation: The day before surgery and the day after surgery Primary outcome measures: * Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide. * PaO2, PaCO2 and oxygen saturation (blood gas)
Detailed description
Postoperative hypoxia complicates 30% - 50% of abdominal surgeries. People at particular risk for postoperative pulmonary complications including severe hypoxia are those who undergo abdominal surgery, emergency surgery or have a respiratory failure due to chronic lung disease including obstructive sleep apnea. The cause of postoperative restrictive lung function and hypoxia is unknown. Previous studies report that PaO2 decreases by an average of 2 kPa after abdominal surgery, while PaCO2 is unchanged and vital capacity decreases by 35%. The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery. Design: Prospective cohort study Inclusion: Patients undergoing surgery for abdominal surgery Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies. Method: The day before surgery and the day after surgery: Lung function (Vital capacity and FEV1) using box and diffusion capacity measurements and blood gas measurement Primary outcome measures: * Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide. * PaO2, PaCO2 and oxygen saturation (blood gas) Other variables examined: age, sex, height, weight, type of surgery, type of anesthesia, smoking status, length of surgery, previously known lung disease.
Interventions
DIAGNOSTIC_TESTLung function before and after surgery
A diagnostic test
Sponsors
Karolinska Institutet
Umeå University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patients (18 years old and older) scheduled for surgery in the abdomen at department of Surgery, Urology and Gynecologi, Umeå University hospital. * Must be able to perform a lung function test
Exclusion criteria
• Dementia or severe cognitive impairment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diffusion capacity for carbon monoxide (DLCO) | Change from baseline (the day before surgery) to postoperative day 1 or 2 | Change in DLCO |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vital capacity (VC) | Change from baseline (the day before surgery) to postoperative day 1 or 2 | Change in VC |
| Forced expiratory volume (FEV1) | Change from baseline (the day before surgery) to postoperative day 1 or 2 | Change in FEV1 |
| Arterial PO2 | Change from baseline (the day before surgery) to postoperative day 1 or 2 | Change in arterial PO2 |
| Arterial PCO2 | Change from baseline (the day before surgery) to postoperative day 1 or 2 | Change in arterial PCO2 |
Countries
Sweden
Outcome results
None listed