Blood Coagulation Disorder
Conditions
Brief summary
Ondansetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of ondansetron. The investigators therefore will perform the present study to measure the effect of ondansestron on the blood coagulation pathway according to the drug concentration level using a thromboelastography test.
Interventions
DRUG0 ul of ondansetron
Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (0 nl) using ondansetron
DRUG0.2 ul of ondansetron
Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (0.2 ul) using ondansetron
DRUG2 ul of ondansetron
Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (2 ul) using ondansetron
DRUG20 ul of ondansetron
Venous blood is taken from 12 healthy volunteers and divided into four specimen bottles, which were added with different doses (20 ul) using ondansetron
Sponsors
Seoul National University Bundang Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy vonlunteers * Age: 20 to 65 years * Body weight \> 50 kg * Volunteers who provided informed consent
Exclusion criteria
* Hematologic disease * Anticoagulant medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Citrated Functional Fibrinogen | During the thromboelastography analysis/ an average of 1 hour | Provides clot strength based on fibrinogen contribution |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Citrated Kaolin Heparinase | During the thromboelastography analysis/ an average of 1 hour | To assess the effect of heparin |
| Citrated Rapid Thromboelastography | During the thromboelastography analysis/ an average of 1 hour | A quicker assessment of clot strength, without assessment of clot initiation |
| Heparinized Kaolin Heparinase | During the thromboelastography analysis/ an average of 1 hour | To measure the platelet function |
| Citrated Kaolin | During the thromboelastography analysis/ an average of 1 hour | Normal thromboelastography |
| Adenosine diphosphate | During the thromboelastography analysis/ an average of 1 hour | To masure the drug effect |
| Arachidonic acid | During the thromboelastography analysis/ an average of 1 hour | To masure the drug effect |
| Activator F | During the thromboelastography analysis/ an average of 1 hour | To eliminate the platelet function |
Countries
South Korea
Contacts
Primary ContactHyo-Seok Na, MD., PhD.
Outcome results
None listed