COVID-19, Echocardiography, Stress, Hypertension, Pulmonary
Conditions
Keywords
Echocardiography, Stress, COVID-19, Pulmonary Hypertension
Brief summary
With the appearance of the new SARS-COV2 virus, additional challenges are being imposed on the medical community after the resolution of acute COVID-19 illness, resulting in specific pathophysiologic mechanisms that while acutely damage the lung parenchyma might chronically impact the cardiopulmonary system. This study aims to investigate changes after mild COVID-19 illness in echocardiographic indices at rest and stress.
Interventions
DIAGNOSTIC_TESTechocardiogram 2D
The patient is accelerating against a workload that gradually increases at a constant rate during the exercise, images will be obtained by echocardiography. The patient begins with 25 Watts with increments of 25 Watts every 3 minutes, continuing the exercise until significant electrocardiographic changes occur or the patient starts with symptoms.
Sponsors
Miguel Ayala León
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Having suffered mild COVID-19 illness * PCR test negative after COVID-19 illness * Men or women * Age ≥18 years and \< 45. * No history of other cardiovascular or lung disease. * No cardiovascular risk factors, that is, arterial systemic hypertension, smoking, diabetes, dyslipidemia * No ongoing or previous cardio or vasoactive treatment * Able to use the semi-supine exercise bicycle * Able to give informed consent
Exclusion criteria
* Poor acoustic window. * Tricuspid regurgitation more than mild * Professional sports activity * Pregnancy * Obesity (body mass index \[BMI\], ≥30 kg/m2). * Inability to provide consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| • E wave mitral | 3 minutes | E wave mitral |
| • A wave mitral | 3 minutes | A wave mitral |
| • E wave /A wave mitral | 3 minutes | E wave /A wave mitral |
| • E-wave at mitral annulus | 3 minutes | E-wave at mitral annulus |
| • LA volume index | 3 minutes | Left atrium volume index |
| • LV telediastolic diameter | 3 minutes | Left ventricle telediastolic diameter |
| • LV telesystolic diameter | 3 minutes | Left ventricle telesystolic diameter |
| • LV posterior wall | 3 minutes | Left ventricle posterior wall |
| • RA area | 3 minutes | Right atrium area |
| • RV basal dimensión | 3 minutes | Right ventricle basal dimensión |
| • RV mid cavity dimension; | 3 minutes | Right ventricle cavity dimensión |
| • RV longitudinal dimension | 3 minutes | Right ventricle longitudinal dimension |
| • Distal, RV outflow tract dimension at the distal or pulmonic valve level | 3 minutes | Distal, right ventricle outflow tract dimension at the distal or pulmonic valve level |
| • Proximal RV outflow tract dimension at the proximal subvalvular level | 3 minutes | Proximal right ventricle outflow tract dimension at the proximal subvalvular level |
| • TAPSE | 3 minutes | • Tricuspid annular plane systolic excursion |
| • RV free Wall strain | 3 minutes | Right ventricle free Wall strain |
| • Inferior cava vein PW Doppler | 3 minutes | Inferior cava vein PW Doppler |
| • E-wave at mitral annulus / A-wave at the mitral annulus | 3 minutes | E-wave at mitral annulus / A-wave at the mitral annulus |
| • E wave/ E-wave at the mitral annulus | 3 minutes | E wave/ E-wave at the mitral annulus |
| • E tricuspid (E) | 3 minutes | E tricuspid (E) |
| • A tricuspid (A) | 3 minutes | A triuspid (A) |
| • E/A | 3 minutes | E/A |
| • Systolic pulmonary artery pressure | 3 minutes | Systolic pulmonary artery pressure |
| • E-wave at the tricuspid annulus | 3 minutes | E-wave at the tricuspid annulus |
| • Mean pulmonary artery pressure | 3 minutes | Mean pulmonary artery pressure |
| • Stroke volume | 3 minutes | Stroke volume |
| • Cardiac output | 3 minutes | Cardiac output |
Countries
Mexico
Contacts
Primary Contactmiguel ayala-leon
Outcome results
None listed