Asthma in Children
Conditions
Keywords
asthma in children, intravenous magnesium sulphate, nebulized magnesium sulphate
Brief summary
The purpose of study is to assess the effectiveness of nebulized magnesium sulphate in children presenting with acute asthma.Study perfoma consists of demographic variables,exclusion criteria and pediatric asthma score that includes respiratory rate,SPO2 at room air(requirement of oxygen),auscultatory findings in chest,dysnea and retractions.
Detailed description
After getting informed consent from guardian,148 patients of acute moderate ro severe asthma with pediatric asthma score 8-15 will be randomly classified into 2 groups and one group will receive nebulization with magnesium sulphate and other will receive intravenous magnesium sulphate and effectiveness will be compared by 4 point reduction in PAS from baseline in either groups after 6 hours.
Interventions
MgSO4 100mg in 20 ml normal saline will be given via ultrasonic nebulizer over 10 minutes,and PAS score will be assessed at 30,60,120,240,360 minutes
pts age 2 to 12 years will receive intravenous magnesium sulphate 50 mg/kg over half hour
Sponsors
King Edward Medical University
Saima Khatoon
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
2 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* patients with age 2 to 12 years with acute moderate to severe exacerbation of asthma as per operational definition children who are unrespoinsive to standard treatment of asthma at 60 minutes
Exclusion criteria
* those with history of chronic lung disease and abnormal renal function contraindication for MgSO4 due to hepatic or renal disease allergy to MgSo4 children who has other comorbid illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of nebulized magnesium sulphate with intravenous magnesium sulphate in children with acute asthma will be assessed by a drop in PAS score, as assessed at 6 hours of intervention. | 6 hours | The intervention will be considered effective if there is a drop of at least 4 points in PAS score at hour-6 of intervention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| duration of ICU stay | 72 hours/3 days | this will be measured in hours |
| duration of hospital stay | 120 hours/5 days | this will be measured in hours |
Countries
Pakistan
Outcome results
None listed