Speech, Consolidation
Conditions
Brief summary
These studies test the hypothesis that sensory areas of the brain participate in the consolidation of speech motor memory by using transcranial magnetic stimulation to suppress activity in somatosensory and auditory cortex following adaptation in order to block retention of learning.
Detailed description
Subjects will train using altered auditory feedback. Immediately following adaptation, continuous theta burst magnetic stimulation (cTBS) will be applied to either auditory or somatosensory or motor cortex with the goal of blocking consolidation of motor memory. The logic of applying cTBS to both sensory areas is to test the hypothesis that both areas are involved in motor memory consolidation. Subjects leave the laboratory following cTBS and return 24 hours later to assess retention of learning. Learning is assessed as percentage change in speech sounds (first formant frequency) relative to baseline.
Interventions
BEHAVIORALAdaptation
Sensorimotor adaptation in speech
OTHERcTBS
continuous theta-burst stimulation
Sponsors
Yale University
McGill University
National Institute on Deafness and Other Communication Disorders (NIDCD)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* right handed adults * no known physical or neurological abnormalities
Exclusion criteria
* patients with: * cardiac pacemaker * surgical clips or values on the heart * implants * metal or metallic fragments in any part of the body * pregnancy * claustrophobia * a personal or family history of epilepsy * currently taking antipsychotic drugs * currently taking antidepressant drugs * currently taking antianxiety drugs * history of concussion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean Percent Change in F1 to Assess Motor Learning | Baseline and end of learning (30 minute session) | Learning is assessed as change in speech sounds (speech formant frequencies, F1) relative to baseline. The first formant frequency (F1) is the lowest resonant frequency of the vocal tract. Lower F1 Numbers Indicate a high or "closed" tongue position). Higher F1 Numbers indicate a low or "open" jaw position. Absolute numbers vary depending on a person's age and vocal tract size. Percent change calculated as ((F1 end of learning value minus F1 baseline value)/ F1 baseline value)\*100). |
| Mean Percent Change in F1 to Assess Retention of Learning | Baseline and 24 hours after learning (re-test lasts 30 minutes) | First formant frequency change (F1) relative to baseline is the dependent measure of retention. Percent change calculated as ((F1 end of retention value minus F1 baseline value)/ F1 baseline value)\*100). |
Countries
Canada
Contacts
PRINCIPAL_INVESTIGATORDavid Ostry
Haskins Laboratories
Baseline characteristics
| Characteristic | — |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 15 Participants |
| Race and Ethnicity Not Collected | 0 Participants |
| Sex: Female, Male Female | 0 Participants |
| Sex: Female, Male Male | 0 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk |
|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 15 | 0 / 15 | 0 / 15 | 0 / 15 |
| other Total, other adverse events | 0 / 15 | 0 / 15 | 0 / 15 | 0 / 15 |
| serious Total, serious adverse events | 0 / 15 | 0 / 15 | 0 / 15 | 0 / 15 |
Outcome results
None listed